Mucoepidermoid Carcinoma, Esophageal
Adenosquamous carcinoma; Mucoepidermoid tumor; Squamous cell carcinoma with mucin-secreting component
Mucoepidermoid carcinoma is a malignant epithelial glandular tumor characterized by the presence, in variable proportions, of mucin-producing, intermediate, and squamoid cells that can undergo columnar, clear, and oncocytic change.
Mucoepidermoid carcinoma is a very rare esophageal neoplasm, accounting for less than 1% of malignant neoplasms.
Most cases of mucoepidermoid carcinoma of the esophagus are reported in patients in their sixth to seventh decades.
Most cases occur in men, with an M/F ratio between 2:1 and 3:1.
Most mucoepidermoid carcinomas arise in the lower two-thirds of the esophagus.
Surgery is the treatment of choice for mucoepidermoid carcinoma, following the guidelines for the treatment of esophageal squamous cell carcinoma. Positive margins and high histological grade warrant postoperative...
References and Further Reading
- Huang, Q., Shi, J., Sun, Q., Fan, X., Feng, A., Wu, H., Zhou, Q., Yu, C., Mashimo, H., & Lauwers, G. Y. (2012). Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Human Pathology.http://dx.doi.org/10.1016/j.humpath.2012.02.018
- Tonon, G., Modi, S., Wu, L., Kubo, A., Coxon, A. B., Komiya, T., O’Neil, K., Stover, K., El-Naggar, A., Griffin, J. D., Kirsh, I. R., & Kaye, F. J. (2003). t(11:19)(q21:p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a NOTCH signalling pathway. Nature Genetics, 33, 208–213.CrossRefPubMedGoogle Scholar