Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Mucinous Carcinoma, Upper Gastrointestinal Tract

  • Chella R. S. van der Post
  • Fátima Carneiro
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1654

Synonyms

Colloid carcinoma; Mucinous adenocarcinoma; Mucoid carcinoma

Definition

Mucinous carcinoma is one of the five main types of gastric adenocarcinoma in the World Health Organization (WHO) classification scheme. These adenocarcinomas are characterized by the production of abundant intracellular and extracellular mucus; by convention, more than 50% of the tumor consists of extracellular mucus.

Clinical Features

  • Incidence

    Gastric carcinoma accounts for the fifth most common form of cancer worldwide. Mucinous gastric carcinoma compromises approximately 2–5% of all gastric carcinomas.

  • Age

    Incidence increases progressively with age and is not different from other types of gastric carcinoma.

  • Sex

    Men are more at risk of developing gastric cancer than women. In the study of Choi et al., 77% of patients with mucinous gastric carcinoma were men, while in non-mucinous gastric carcinoma, 67% were men.

  • Site

    The entire stomach can be involved; most frequently, mucinous gastric carcinomas are...

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References and Further Reading

  1. Bosman, F. T., Carneiro, F., Hruban, R. H., & Theise, N. D. (2010). WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.Google Scholar
  2. Choi, J. S., Kim, M. A., Lee, H. E., Lee, H. S., & Kim, W. H. (2009). Mucinous gastric carcinomas: Clinicopathologic and molecular analyses. Cancer, 115(15), 3581–3590.CrossRefPubMedGoogle Scholar
  3. Chu, P. G., Chung, L., Weiss, L. M., & Lau, S. K. (2011). Determining the site of origin of mucinous adenocarcinoma: An immunohistochemical study of 175 cases. The American Journal of Surgical Pathology, 35(12), 1830–1836.CrossRefPubMedGoogle Scholar
  4. Sung, C. O., Lee, S. M., Choi, J. S., Kim, K. M., Choi, M. G., Noh, J. H., et al. (2012). Tumor size predicts survival in mucinous gastric carcinoma. Journal of Surgical Oncology, 106(6), 757–764.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands
  2. 2.Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3SPortoPortugal