Synonyms
Gastric carcinoma with a lymphoid stroma; Lymphoepithelial-like carcinomas; Medullary carcinoma with lymphocytic infiltration; Undifferentiated carcinoma with lymphoid stroma
Definition
Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated carcinoma with prominent lymphoid stroma (Glickman and Odze 2009), which is similar to nasopharyngeal carcinomas. This type of tumor has been described in a number of extragastrointestinal sites, such as thyroid or breast, and also along the gastrointestinal tract (Delaney and Chetty2012). In the latter, the most commonly reported site is the stomach, but cases arising in the esophagus and colon have been described (Delaney and Chetty2012). Rarely, this type of tumor has been reported in the liver and biliary tree (Ishida et al. 2011).
LELC has been classically associated with Epstein-Barr virus (EBV) infection. In the stomach, more than 80% of cases have evidence of EBV infection, while in esophageal LELC, in one study, only 3%...
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Delaney, D., & Chetty, R. (2012). Lymphoepithelioma-like carcinoma of the colon. International Journal of Clinical and Experimental Pathology, 5(1), 105–110.
Fukayama, M., & Ushiku, T. (2011). Epstein-Barr virus-associated gastric carcinoma. Pathology, Research and Practice, 207(9), 529–537.
Glickman, J., & Odze, R. D. (2009). Epithelial neoplasms of the esophagus. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.
Ishida, M., Mori, T., Shiomi, H., et al. (2011). Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct. World Journal of Gastrointestinal Oncology, 3(7), 111–115.
Kojima, Y., Mogaki, M., Takagawa, R., et al. (2007). A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis. Journal of Gastroenterology, 42(2), 181–185.
Lauwers, G. Y. (2009). Epithelial neoplasms of the stomach. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.
Lee, W. (2011). Intrahepatic lymphoepithelioma-like cholangiocarcinoma not associated with Epstein-Barr virus: A case report. Case Reports in Oncology, 4(1), 68–73.
Nakasono, M., Hirokawa, M., Suzuki, M., et al. (2007). Lymphoepithelioma-like carcinoma of the esophagus: Report of a case with non-progressive behavior. Journal of Gastroenterology and Hepatology, 22(12), 2344–2347.
Tamura, T., Hamada, T., Sako, T., et al. (2010). Lymphoepithelioma-like carcinoma of the stomach with epithelioid granulomas. Case Reports in Gastroenterology, 4(3), 361–368.
Wang, H., Wu, M., Shun, C., et al. (1999). Lymphoepithelioma-like carcinoma of the stomach: A subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection. Hepato-Gastroenterology, 46(26), 1214–1219.
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Baldaia, H. (2017). Lymphoepithelioma-Like Carcinoma. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1650
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1650
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