Lymphocytic gastritis is a pathological reaction pattern common to a variety of entities (Lash et al.2009). It is characterized by an intense lymphocytic infiltrate in the gastric mucosa with permeation of the foveolar epithelium. It is mainly associated with celiac disease and H. pylori infection but it also complicates Crohn’s disease, HIV infection, Menétrier disease, hypersensitivity reactions, autologous hematopoietic cell transplantation, lymphoma, and esophageal carcinoma (Fenoglio-Preiser et al.2008).
The etiology is still unknown. The strong association with celiac disease and the fact that the intraepithelial lymphocytes are CD8+ T cells have raised the hypothesis of an allergic or autoimmune pathogenesis (Lash et al. 2009).
The most common symptoms are weight loss and anorexia (Lash et al. 2009).
References and Further Reading
- Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). The nonneoplastic stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 197–199). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
- Lash, R. H., Lauwers, G. Y., Odze, R. D., & Genta, R. M. (2009). Inflammatory disorders of the stomach. In R. Odze & J. R. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Saunders.Google Scholar