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Pathology of the Gastrointestinal Tract pp 393–396Cite as

Inflammatory Myofibroblastic Tumor, Upper Gastrointestinal Tract

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Inflammatory myofibroblastoma; Inflammatory myofibrohistiocytic proliferation; Inflammatory pseudotumor; Plasma cell granuloma; Plasma cell pseudotumor

Definition

The inflammatory myofibroblastic tumor comprises spindle or polygonal fibroblast-/myofibroblast-type cells, which often express anaplastic lymphoma kinase (ALK), and stromal lymphoplasmacytic inflammatory cells. Some authors have differentiated inflammatory myofibroblastic tumors from reactive pseudosarcomatous processes and other neoplasms based on ALK immunoreactivity or evidence of the ALK translocation, but many consider ALK-negative inflammatory myofibroblastic tumors a valid diagnostic category.

Clinical Features

  • Incidence

    Inflammatory myofibroblastic tumors (IMTs) are rare in the upper gastrointestinal (GI) tract.

  • Age

    Inflammatory myofibroblastic tumors mean age (range) is 41 years (0.75–84) (Makhlouf and Sobin 2002).

  • Sex

    The male to female ratio of inflammatory myofibroblastic tumors is 1.1:1 (Makhlouf and...

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References and Further Reading

  • Coffin, C. M., Watterson, J., Priest, J. P., & Dehner, L.-P. (1995). Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. The American Journal of Surgical Pathology, 19, 859–872.

    Article  CAS  Google Scholar 

  • Fisher, C. (2011). Immunohistochemistry in diagnosis of soft tissue tumours. Histopathology, 58, 1001–1012.

    Article  Google Scholar 

  • Kelleher, F. C., & McDermott, R. (2010). The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene. European Journal of Cancer, 46(13), 2357–2368.

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  • Makhlouf, H. R., & Sobin, L. H. (2002). Inflammatory myofibroblastic tumors (inflammatory pseudotumors) of the gastrointestinal tract: How closely are they related to inflammatory fibroid polyps? Human Pathology, 33, 307–315.

    Article  Google Scholar 

  • Patel, A. S., Murphy, K. M., Hawkins, A. L., Cohen, J. S., Long, P. P., Perlman, E. J., & Griffin, C. A. (2007). RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors. Cancer Genetics and Cytogenetics, 176, 107–114.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr. Roberto Frias S/N, 4200-465, Porto, Portugal

    José Manuel Lopes

Authors
  1. José Manuel Lopes
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Corresponding author

Correspondence to José Manuel Lopes .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Cite this entry

Lopes, J.M. (2017). Inflammatory Myofibroblastic Tumor, Upper Gastrointestinal Tract. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1640

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1640

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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