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Pathology of the Gastrointestinal Tract pp 353–358Cite as

Hyperplastic Polyps (Stomach)

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Gastritis polyposa; Hyperplasiogenic polyp; Inflammatory polyp; Regenerative polyp

Definition

Hyperplastic polyps are localized, non-neoplastic mucosal expansions consisting of elongated, tortuous, and cystically dilated foveolae supported by an edematous lamina propria and distended vessels. Hyperplastic polyps arise probably as a result of reparative and regenerative responses to mucosal injury. First there is ongoing healing and a reparative response in the form of foveolar hyperplasia after mucosal injury and erosion. This hyperplastic reaction can end or persist and progress with the formation of a hyperplastic polyp. The common causative agents of mucosal injury are Helicobacter pylori and autoimmune gastritis leading to chronic gastritis, although any agent causing chronic gastritis may be a predisposing condition. H. pylorihas been shown to increase the expression of cyclo-oxygenase-2 (COX-2), interleukin 1-beta, and hepatocyte growth factor in stromal cells, which...

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References and Further Reading

  • Abraham, S. C., Singh, V. K., Yardley, J. H., & Wu, T. T. (2001). Hyperplastic polyps of the stomach: Associations with histologic patterns of gastritis and gastric atrophy. American Journal of Surgical Pathology, 25(4), 500–507.

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  • Carneiro, F., David, L., Seruca, R., Castedo, S., Nesland, J. M., & Sobrinho-Simões, M. (1993). Hyperplastic polyposis and diffuse carcinoma of the stomach. A study of a family. Cancer, 72, 323–329.

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  • Carneiro, F., Santos, L., & Sobrinho-Simões, M. (1995). Carcinoma arising in gastric hyperplastic polyps. Gastrointestinal Endoscopy, 41, 178–179.

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  • Goddard, A. F., Badreldin, R., Pritchard, D. M., Walker, M. M., Warren, B., & British Society of Gastroenterology. (2010). The management of gastric polyps. Gut, 59(9), 1270–1276.

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  • Hattori, T. (1985). Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach. Journal of Clinical Pathology, 38(6), 622–630.

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  • Jain, R., & Chetty, R. (2009). Gastric hyperplastic polyps: A review. Digestive Diseases and Sciences, 54(9), 1839–1846.

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  • Yao, T., Kajiwara, M., Kuroiwa, S., Iwashita, A., Oya, M., Kabashima, A., et al. (2002). Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression. Human Pathology, 33(10), 1016–1022.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands

    Chella R. S. van der Post

  2. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal

    Fátima Carneiro

Authors
  1. Chella R. S. van der Post
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  2. Fátima Carneiro
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Corresponding author

Correspondence to Chella R. S. van der Post .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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van der Post, C.R.S., Carneiro, F. (2017). Hyperplastic Polyps (Stomach). In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1636

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1636

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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