Collagenous gastritis is a rare entity characterized by the presence of an irregular and discontinuous subepithelial band of collagen of more than 10 μm in thickness in the gastric mucosa (Ravikumara et al. 2007).
The pathogenesis of this disease is still unknown. The most commonly accepted hypothesis is that the striking collagen deposition represents a reparative process subsequent to mucosal damage from chronic inflammation, an infectious agent, or toxic injury. This is supported by the fact that Type I and Type III collagen are associated with repair and have been demonstrated in the subepithelial collagen band present in this condition. An abnormality of the pericryptal fibroblast sheath or leakage of plasma protein with replacement with collagen has also been proposed to explain the collagen deposition (Ravikumara et al.2007).
Collagenous gastritis is a rare disorder with scarce reports in the literature since...
References and Further Reading
- Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). Inflammatory disorders of the stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text. Philadelphia: Lippincott Williams & Wilkins.Google Scholar
- Winslow, J. L., Trainer, T. D., & Colletti, R. B. (2001). Collagenous gastritis: A long-term follow-up with the development of endocrine cell hyperplasia, intestinal metaplasia, and epithelial changes indeterminate for dysplasia. American Journal of clinical pathology, 116(5), 753–758.PubMedGoogle Scholar