Fundic Gland Polyp
Cystic hamartomatous epithelial (gastric) polyp; Elster’s (gland) cyst; FGP; Fundic gland hyperplasia
Fundic gland polyps (FGPs) are small polyps typically located in the gastric corpus and fundus. Elster et al. first described them as a distinct pathological polyp in 1977. Their characteristic morphology shows cystically dilated glands lined by mucous neck cells, parietal cells, and/or chief cells. FGPs arise in two settings, namely, sporadic and familial adenomatous polyposis (FAP) syndrome-associated settings. FGPs are among the most common gastric polyps in both sporadic and FAP patients. In comparison to sporadic FGPs, FAP-associated FGPs are more likely to be multiple and to occur at younger age. Sporadic fundic gland polyposis (≥10 FGPs) is occasionally observed in the non-FAP population.
The pathogenesis of FGPs is not well understood. FGPs have formerly been regarded as nonneoplastic lesions, either hamartomatous or hyperplastic/functional in nature. It has...
References and Further Reading
- Abraham, S. C. (2010). Fundic gland polyps: Common and occasionally problematic lesions. Gastroenterol Hepatol (NY), 6(1), 48–51.Google Scholar
- Jalving, M., Koornstra, J. J., Boersma-van Ek, W., de Jong, S., Karrenbeld, A., Hollema, H., et al. (2003). Dysplasia in fundic gland polyps is associated with nuclear beta-catenin expression and relatively high cell turnover rates. Scandinavian Journal of Gastroenterology, 38(9), 916–922.CrossRefPubMedGoogle Scholar
- Li, J., Woods, S. L., Healey, S., et al. (2016). Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. American Journal of Human Genetics, 98(5), 830–842.Google Scholar
- Worthley, D. L., Phillips, K. D., Wayte, N., et al. (2012). Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut, 61(5), 774–779.Google Scholar