Epstein-Barr Virus (EBV), Esophagitis
Human herpesvirus four esophagitis
Epstein-Barr virus (EBV) esophagitis is a form of esophagitis caused by herpesvirus in immunocompetent or immunocompromised patients.
EBV is a ubiquitous virus that infects and establishes a persistent infection in the host. Clinically, it causes two types of infection: the primary infection, which ranges from a mild self-limited illness in children to infectious mononucleosis in adolescents and adults, and the reactivation of latent infection in immunocompromised patients (Gesser 1997). EBV replicates and is shed periodically from epithelial cells in the oropharynx or from salivary glands and persists through interactions with two different host cell types: epithelial cells at the surface of the body that are fully permissive for the production of infectious virus and serve to transmit the virus from person to person and cells situated deeper in the body that generally are nonpermissive and function as a reservoir of latent virus.