Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Neuroendocrine Tumor, Gastric

  • José Manuel Lopes
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1588

Synonyms

Mixed adenoneuroendocrine carcinomas (MANECs); Neuroendocrine carcinomas (NECs); Neuroendocrine tumors (NETs)

Definition

Neuroendocrine neoplasms of the digestive system (Rindi et al. 2010), namely, in the stomach (g-NENs), include (1) Neuroendocrine tumors (NETs) – carcinoids and well-differentiated endocrine tumors/carcinomas; (2) Neuroendocrine carcinomas (NECs): poorly differentiated endocrine carcinomas, high-grade neuroendocrine carcinomas, small-cell and large-cell endocrine carcinomas; and (3) Mixed adenoneuroendocrine carcinomas (MANECs) (Solcia et al. 2010); there are also hyperplastic and preneoplastic neuroendocrine lesions. Precursor neuroendocrine lesions of the stomach that occur in hypergastrinemic conditions (autoimmune chronic atrophic gastritis, multiple endocrine neoplasia type 1, and Zollinger-Ellison syndrome) include (a) enterochromaffin-like cell (ECL) hyperplasia (linear, micronodular <150 μm, and adenomatoid) and (b) dysplasia(enlarged micronodules...

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References and Further Reading

  1. Fave, G. D., Kwekkeboom, D. K., Cutsem, E. V., Rindi, G., Kos-Kudla, B., Knigge, U., Sasano, H., Tomasseti, P., Salazar, R., Rusznieweski, P., & Barcelona Consensus Conference participants. (2012). ENETS consensus guidelines for the management of patients with gastroduodenal neoplasms. Neuroendocrinology, 95, 74–87.CrossRefGoogle Scholar
  2. Rindi, G., Kloppel, G., Alhman, H., Caplin, M., Couvelard, A., de Herder, W. W., Erikssson, B., Falchetti, A., Falconi, M., Komminoth, P., Korner, M., Lopes, J. M., McNicol, A. M., Nilsson, O., Perren, A., Scarpa, A., Scoazec, J. Y., Wiedenmann, B., & Frascati Consensus Conference Participants. (2006). TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Archiv, 449, 395–401.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Rindi, G., Kloppel, G., Couvelard, A., Kommonoth, P., Korner, M., Lopes, J. M., NcNicol, A. M., Nilsson, O., Perren, A., Scarpa, A., Scoazec, J. Y., & Wiedenmann, B. (2007). TNM staging of midgut and hindgut (neuro) endocrine tumors: A consensus proposal including a grading system. Virchows Archiv, 451, 757–762.CrossRefPubMedGoogle Scholar
  4. Rindi, G., Arnold, R., Bosman, F. T., Capella, C., Klimstra, D. S., Kloppel, G., & Solcia, E. (2010). Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 13–14). Lyon: International Agency for Research on Cancer (IARC).Google Scholar
  5. Solcia, E., Arnold, R., Capella, C., Klimstra, D. S., Kloppel, G., Kominoth, P., & Rindi, G. (2010). Neuroendocrine neoplasms of Stomach. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 64–68). Lyon: International Agency for Research on Cancer (IARC).Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of PortoPortoPortugal