Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Dieulafoy’s Lesion

  • Francisco Ferro de BeçaEmail author
  • Elisabete Rios
Reference work entry


Caliber-persistent artery; Exulceratio simplex; Gastric atherosclerotic aneurysm


Named after Paul Georges Dieulafoy (1839–1911), a French surgeon and professor of pathology, Dieulafoy’s lesion is a cause of acute GI bleeding. This is a potentially life-threatening lesion due to the presence of an enlarged artery in the submucosa that protrudes through small (2–5 mm) mucosal defects with exposure of the vessel wall in the lumen causing intraluminal hemorrhage. Dieulafoy’s lesion is often recurrent and causes obscure massive GI hemorrhage, manifested by hematemesis and/or melena (Ding et al. 2010). Patients usually have no prior history of GI pathology or symptoms and typically have no significant NSAIDs or alcohol use. Although this lesion presents more commonly in a population with comorbidities, such as cardiopulmonary dysfunction or renal failure, which has led some researchers to propose causal links with these diseases, etiology for Dieulafoy’s lesion remains...

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References and Further Reading

  1. Baxter, M., & Aly, E. H. (2010). Dieulafoy’s Lesion: Current trends in diagnosis and management. Annals of the Royal College of Surgeons of England, 92, 548–554.CrossRefGoogle Scholar
  2. Ding, Y., Zhao, L., Liu, J., & Luo, H. S. (2010). Clinical and endoscopic analysis of gastric Dieulafoy’s lesion. World Journal of Gastroenterology, 16(5), 631–635.CrossRefGoogle Scholar
  3. Montgomery, E. A., & Voltagio, L. (2012). Chapter 2, Stomach. In: Biopsy interpretation of the gastrointestinal tract mucosa. Vol 1: Non-neoplastic. 2nd ed, (pp. 89–91). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  4. Jain, R., & Chetty, R. (2009). Dieulafoy disease of the colon. Archives of Pathology & Laboratory Medicine, 133(11), 1865–1867.Google Scholar
  5. Senger, J. L., & Kanthan, R. (2012). The evolution of Dieulafoy’s Lesion since 1897: Then and now-a journey through the lens of a pediatric lesion with literature review. Gastroenterology Research and Practice. 2012: 432517.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Francisco Ferro de Beça
    • 1
    • 2
    • 3
    Email author
  • Elisabete Rios
    • 1
    • 2
    • 3
  1. 1.Department of PathologyCentro Hospitalar de São JoãoPortoPortugal
  2. 2.Faculty of Medicine of the University of PortoPortoPortugal
  3. 3.IPATIMUP – Institute of Pathology and Molecular Immunology of the University of PortoPortoPortugal