Synonyms
CD117; C-Kit synonyms include C-Kit; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; Proto-oncogene c-Kit; Proto-oncogene tyrosine-protein kinase Kit; SCFR; Soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Definition
C-Kit (CD117) is an antibody that identifies the C-Kit protein.
Molecule Type and Chemical Structure
C-Kit belongs to the type III receptor tyrosine kinase (RTK) subfamily, whose members include platelet-derived growth factor receptors α and β (PDGFRα and PDGFRβ) (Roskoski 2005). All type III RTKs contain five immunoglobulin-like domains in their extracellular ligand-binding region followed by a single transmembrane domain and a cytoplasmic tyrosine kinase domain interrupted by a large kinase insert. The ligand of KIT is known as stem cell factor. C-Kit(the gene) is transcribed and ultimately translated into the KIT protein, a transmembrane receptor tyrosine...
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Corless, C. L., Barnett, C. M., & Heinrich, M. C. (2011). Gastrointestinal stromal tumours: Origin and molecular oncology. Nature Reviews Cancer, doi:10.1038/nr3143.
Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Muhammad, T. G., Matsuzawa, Y., Kanakura, Y., Shinomura, Y., & Kitamura, Y. (1998). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 279, 577–580.
Lennartsson, J., & Rönnstrand, L. (2006). The stem cell factor receptor/c-Kit as a drug target in cancer. Current Cancer Drug Targets, 6, 561–571.
Roskoski, R. (2005). Structure and regulation of Kit protein-tyrosine kinase – The stem cell factor receptor. Biochemical and Biophysical Research Communications, 338, 1307–1315.
Wong, N. A. C. S. (2011). Gastrointestinal stromal tumours – An update for histopathologists. Histopathology, 59, 807–821.
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Lopes, J.M. (2017). C-Kit (CD117), Gastrointestinal Stromal Tumors (GISTs). In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1572
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1572
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