Gastric Cardia (Proximal Stomach)
The stomach is divided into four anatomic regions: cardia, fundus, corpus, and antropyloric. The gastric cardia is a narrow, ill-defined region and is not grossly distinctive or sharply demarcated. It represents the area of the mucosa located distal to the anatomic gastroesophageal junction and proximal to the body of the stomach (fundus/corpus) that is composed entirely of oxyntic glands. The cardia is a very short segment (<0.4 cm) of the mucosa that is typically composed of pure mucous glands or mixed mucous and oxyntic glands.
The extent of the cardiac mucosa and even its existence as a component of the normal stomach has been disputed. In many studies an attempt has been performed to delineate the normal histology of the true gastric cardia, using biopsies, resections, or autopsy specimens. Some studies, mainly in adults, reported the presence of gastric cardia in only 50% of the studied population. A significant proportion of patients with...
References and Further Reading
- De Hertogh, G., Van Eyken, P., Ectors, N., & Geboes, K. (2005). On the origin of cardiac mucosa: A histological and immunohistochemical study of cytokeratin expression patterns in the developing esophagogastric junction region and stomach. World Journal of Gastroenterology, 11(29), 4490–4496.PubMedPubMedCentralGoogle Scholar
- Filipe, M. I. (1979). Mucins in the human gastrointestinal epithelium: A review. Investigative & Cell Pathology, 2(3), 195–216.Google Scholar