Barrett’s metaplasia; Esophageal columnar metaplasia
Barrett’s esophagus (BE) results from the metaplastic replacement of the normal squamous esophageal lining by a columnar epithelium. Currently, there are two distinct definitions of BE stating two different proposals of patient’s management. The American Gastroenterological Association (AGA) defines BE as “the condition in which any extent of metaplastic columnar epithelium that predisposes to cancer development replaces the stratified squamous epithelium that normally lines the distal esophagus.” Currently, the AGA understanding is that “intestinal metaplasia is required for the diagnosis of Barrett’s esophagus because intestinal metaplasia is the only type of esophageal columnar epithelium that clearly predisposes to malignancy” (The AGA Institute Medical Position Panel 2011). The British Society of Gastroenterology (BSG), on the other hand, defines BE as “an endoscopically apparent area above the...