Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Adenosquamous Carcinoma, Upper GI Tract

  • Maria Gabriela GasparinhoEmail author
  • Isabel Fonseca
Reference work entry


There are no current synonyms for this neoplasm. Historically, it has been often confounded with mucoepidermoid carcinoma.


A malignant epithelial neoplasm that has mixed elements of glandular and squamous cell differentiation, which remains clearly distinguishable within the tumor.

Clinical Features

  • Incidence

    Adenosquamous carcinoma (ASC) is a rare disease. No worldwide incidence data is available. In the largest published series, it represented 1.0% of all esophageal cancers.

  • Age

    In the largest published series, patients’ age range from 51 to 85 years, with a mean age of 64 years.

  • Sex

    The disease is more frequent in males.

  • Site

    Adenosquamous carcinoma is somewhat more frequent in the middle and lower thirds of the esophagus.

  • Treatment

    Surgery is the treatment of choice and can be followed by radiotherapy. This particular histological type does not change the usual treatment for esophageal carcinomas.

  • Outcome

    ASC seems to have a better prognosis than conventional...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Alos, L., Castillo, M., Nadal, A., Caballero, M., Mallofre, C., Palacin, A., & Cardesa, A. (2004). Adenosquamous carcinoma of the head and neck: Criteria for diagnosis in a study of 12 cases. Histopathology, 44, 570–579.PubMedGoogle Scholar
  2. Rees, B. P., Rouse, R. W., Wit, M., Noesel, C. J. M., Tytgat, G. N. J., Lanschot, J. B., & Offerhaus, G. J. A. (2002). Molecular evidence for the same clonal origin of both components of an adenosquamous Barrett carcinoma. Gastroenterology, 122, 784–788.PubMedGoogle Scholar
  3. Yachida, S., Nakanishi, Y., Shimoda, T., Nimura, S., Igaki, H., Tachimori, Y., & Kato, H. (2004). Adenosquamous carcinoma of the esophagus, clinicopathologic study of 18 cases. Oncology, 66, 218–225.PubMedGoogle Scholar
  4. Ylagan, L. R., Scholes, J., & Demopoulos, R. (2000). CD44, a marker of squamous differentiation in adenosquamous neoplasms. Archives of Pathology and Laboratory Medicine, 124, 212–215.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Instituto Português de Oncologia de Lisboa Francisco GentilLisboaPortugal
  2. 2.Instituto de Anatomia Patológica da Faculdade de Ciências da Saúde da Universidade da Beira InteriorCovilhãPortugal
  3. 3.Serviço de Anatomia Patológica, Instituto Português de Oncologia Francisco Gentil – LisboaLisbonPortugal
  4. 4.Faculdade de Medicina de Lisboa, Instituto de Anatomia PatológicaLisbonPortugal