First named by Rywlin and Ortega (1970), glycogenic acanthosis is an esophageal disorder characterized by multifocal white plaques of hyperplastic squamous epithelium with abundant intracellular glycogen deposits (Lopes et al. 2010). Its pathogenesis remains unclear; no positive correlation has been made between glycogenic acanthosis and dietary habitus, the use of tobacco, or significant alcoholic intake (Glick et al. 1982). It has been suggested that this entity could be a nonspecific pattern of epithelial response to anatomical site-specific injury (Fyfe and Garcia 1998). However, an association between glycogenic acanthosis and gastroesophageal reflux disease has been reported (Berliner et al. 1981; Lopes et al. 2010), Cowden’s syndrome (Coriat et al. 2011; Kay et al. 1997; Lashner et al. 1986; McGarrity et al. 2003), and Celiac disease (Suoglu et al. 2004). Unless there is a coexisting disease, patients with glycogenic acanthosis are...