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Pathology of the Gastrointestinal Tract pp 557–560Cite as

Nonsteroidal Anti-Inflammatory Drug-Induced Gastrointestinal Injury

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Diaphragm disease

Definition

Nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury ranges from erosion and ulceration to more severe complications such as gastrointestinal bleeding, perforation, or bowel strictures. The association between NSAID use and ulceration in the upper gastrointestinal tract was first reported in 1938 by a gastroscopic study of Douthwaite and Lintott. Since then, this type of lesions has been well characterized and documented. Their pathogenesis is related to the inhibitory role of NSAID on cyclo-oxygenase (COX)-1 and -2, resulting in inhibition of prostaglandin synthesis. Beside the intended anti-inflammatory effect, decreased prostaglandin production can also result in gastroduodenal injury, because prostaglandins enhance and stimulate many aspects of mucosal defense. Topical irritant effects of NSAID are described to contribute to the development of erosions and ulcerations in the gastrointestinal tract. For the gastroduodenal...

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References and Further Reading

  • Geboes, K., De Hertogh, G., & Ectors, N. (2006). Drug-induced pathology in the large intestine. Current Diagnostic Pathology, 12, 239–247.

    Article  Google Scholar 

  • Lang, J., Price, A. B., Levi, A. J., Burke, M., Gumpel, J. M., & Bjarnason, I. (1988). Diaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs. Journal of Clinical Pathology, 41, 516–526.

    Article  CAS  Google Scholar 

  • Price, A. B. (2003). Pathology of drug-associated gastrointestinal disease. British Journal of Clinical Pharmacology, 56, 477–482.

    Article  Google Scholar 

  • Wallace, J. L. (2012). NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies. British Journal of Pharmacology, 165, 67–74.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Liesbeth Ferdinande

Authors
  1. Liesbeth Ferdinande
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Corresponding author

Correspondence to Liesbeth Ferdinande .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Cite this entry

Ferdinande, L. (2017). Nonsteroidal Anti-Inflammatory Drug-Induced Gastrointestinal Injury. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1518

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1518

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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