Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Mucinous Cystadenoma, Appendix

  • Magali Svrcek
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1513

Synonyms

Adenoma of the appendix; Low-grade appendiceal mucinous neoplasm (LAMN); Low-grade appendiceal mucinous tumor

Definition

Appendiceal adenomas are defined as lesions that are confined to the appendix with no evidence of invasion beyond the muscularis mucosae.

Appendiceal adenomas are of two main types. The most common type involves the appendiceal mucosa in a widespread, circumferential fashion. In these, excessive secretion of mucus by neoplastic epithelial cells within the confined appendiceal lumen frequently gives rise to cystic dilatation, creating a mucinous cystadenoma. Less commonly, adenomas of the appendix grow as localized, pedunculated, or sessile lesions.

Some authors recommend not using the term “cystadenoma” anymore, since cystic change does not indicate a separate disease category.

The lesion may contain either low-grade or high-grade dysplasia.

Clinical Features

  • Incidence

    Appendiceal tumors represent less than 0.4% of all intestinal neoplasms. The most common...

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References and Further Reading

  1. Carr, N. J., McCarthy, W. F., & Sobin, L. H. (1995). Epithelial noncarcinoid tumors and tumor-like lesions of the appendix: A clinicopathologic study of 184 patients with a multivariate analysis of prognostic factors. Cancer, 75, 757–768.CrossRefPubMedGoogle Scholar
  2. Misdraji, J., Yantiss, R. K., Graeme-Cook, F. M., et al. (2003). Appendiceal mucinous neoplasms. A clinicopathologic analysis of 107 cases. American Journal of Surgical Pathology, 27, 1089–1103.CrossRefPubMedGoogle Scholar
  3. Nishikawa, G., Sekine, S., Ogawa, R., et al. (2013). Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms. British Journal of Cancer, 108, 951–958.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Pai, R. K., Beck, A. H., Norton, J. A., & Longacre, T. A. (2009). Appendiceal mucinous neoplasms. Clinicopathologic study of 116 cases with analysis of factors predicting recurrence. American Journal of Surgical Pathology, 33, 1425–1439.CrossRefPubMedGoogle Scholar
  5. Yantiss, R. K., Shia, J., Klimstra, D. S., et al. (2009). Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. American Journal of Surgical Pathology, 33, 248–255.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Hôpital Saint-Antoine, Service d’Anatomie PathologiqueAP-HP, Hôpitaux Universitaires de l’Est ParisienParisFrance