Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Microvillous Inclusion Disease

  • Arzu Ensari
Reference work entry


Congenital microvillous atrophy; Davidson disease; Familial microvillous atrophy; Intestinal microvillous atrophy; Intestinal microvillous dystrophy; Microvillous atrophy


Microvillous inclusion disease is an uncommon congenital enteropathy characterized by severe, intractable diarrhea within the first weeks of life. The affected infants have a clinical presentation including the presence of diarrhea for more than 2 weeks, severe nutritional malabsorption, and negative stool cultures. The disease was first described by Davidson in 1978 severe secretory diarrhea occurring during the first week of life with villous atrophy in the intestinal biopsy.

Clinical Features

  • Incidence

    Rare condition. More than 50 cases of MID have been reported so far in the English literature.

  • Age

    It is a disease of neonates and infants in the first 6 months of life. MID manifests either in the first days (early-onset form) or in the first 2 months (late-onset form) of life. The peak age of...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Cutz, E., Sherman, P. M., & Davidson, G. P. (1997). Enteropathies associated with protracted diarrhea of infancy: Clinicopathological features, cellular and molecular mechanisms. Pediatric Pathology & Laboratory Medicine, 17(3), 335–368.Google Scholar
  2. Groisman, G. M., Amar, M., & Livne, E. (2002). CD10, a valuable tool for the light microscopic diagnosis of microvillous inclusion disease (familial microvillous atrophy). The American Journal of Surgical Pathology, 26(7), 902–907.CrossRefPubMedGoogle Scholar
  3. Khubchandani, S. R., Vohra, P., Chitale, A. R., & Sidana, P. (2011). Microvillous inclusion disease-an ultrastructural diagnosis: With a review of the literature. Ultrastructural Pathology, 35, 87–91.CrossRefPubMedGoogle Scholar
  4. Shaila, R. K., Pankaj, V., Arun, R. C., & Poonam, S. (2011). Microvillous inclusion disease-an ultrastructural diagnosis: With a review of the literature. Ultrastructural Pathology, 35, 87–91.CrossRefGoogle Scholar
  5. Szperl, A. M., Golachowska, M. R., Bruinenberg, M., Prekeris, R., Thunnissen, A. M., Karrenbeld, A., Dijkstra, G., Hoekstra, D., Mercer, D., Ksiazyk, J., Wijmenga, C., Wapenaar, M. C., Rings, E. H., & van IJzendoorn, S. C. (2011). Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. Journal of Pediatric Gastroenterology and Nutrition, 52, 307–313.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolSihhiyeTurkey