Skip to main content
SpringerLink
Log in

Serrated Polyposis Syndrome

  • Reference work entry
  • First Online:
Pathology of the Gastrointestinal Tract

Part of the book series: Encyclopedia of Pathology ((EP))

  • 202 Accesses

Synonyms

Hyperplastic polyposis syndrome; Serrated adenomatous polyposis syndrome

Definition

Serrated polyposis syndrome is a clinically defined syndrome characterized by the occurrence of multiple serrated polyps in the large intestine. The definition of serrated polyposis syndrome (SPS) includes (1) at least 5 serrated polyps proximal to the sigmoid with two or more being larger than 10 mm, (2) any number of serrated polyps proximal to sigmoid in an individual who has a first-degree relative with serrated polyposis, and (3) more than 20 serrated polyps of any size distributed throughout the colon. SPS is usually asymptomatic with no associated extracolonic manifestations. Two clinical forms have been described, namely, type 1 characterized by larger and proximally located serrated polyps commonly showing BRAF mutations and/or MMR gene methylation and MSI and a high risk of cancer, whereas type 2 is characterized by numerous small hyperplastic polyps which show KRAS mutations and...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 329.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References and Further Reading

  • Crowder, C. D., Sweet, K., Lehman, A., & Frankel, W. L. (2012). Serrated polyposis is an underdiagnosed and unclear syndrome: The surgical pathologist has a role in improving detection. The American Journal of Surgical Pathology, 36(8), 1178–1185.

    Article  Google Scholar 

  • Guarinos, C., Sánchez-Fortún, C., Rodríguez-Soler, M., Alenda, C., Payá, A., & Jover, R. (2012). Serrated polyposis syndrome: Molecular, pathological and clinical aspects. World Journal of Gastroenterology, 18(20), 2452–2461.

    Article  CAS  Google Scholar 

  • Kalady, M. F., Jarrar, A., Leach, B., Laguardia, L., O’malley, M., Eng, C., & Church, J. M. (2011). Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. Diseases of the Colon and Rectum, 54(2), 164–170.

    Article  Google Scholar 

  • Snover, D. C. (2011). Update on the serrated pathway to colorectal carcinoma. Human Pathology, 42(1), 1–10, Epub 2010 Sep 24.

    Article  Google Scholar 

  • Snover, D. C., Ahnen, D. J., Burt, R. W., & Odze, R. D. (2010). Serrated polyps of the colon and rectum and serrated polyposis. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey

    Arzu Ensari

Authors
  1. Arzu Ensari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arzu Ensari .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Ensari, A. (2017). Serrated Polyposis Syndrome. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1487

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1487

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation