Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Condyloma, Anal

  • Denis Chatelain
  • Jean-François Fléjou
Reference work entry


Anal wart


Anal condyloma is a benign squamous epithelial lesion caused by Human Papilloma Virus (HPV) infection.

Several pathways can transmit HPV: sexual contact, autoinoculation, or contact with infected materials. The incubation period usually lasts 2–3 months before the development of condyloma. HPV 6 and 11 are the cause of over 90% of the exophytic anal warts (anal condyloma acuminatum), and they tend to be associated with low-grade dysplastic cellular changes (or anal intraepithelial neoplasia – AIN), and with other low-risk HPV subtypes such as 16 and 39. HPV 16 and 18 are responsible for most of the chronic infections that cause flat squamous lesions, often with high-grade dysplasia, favoring the development of squamous cell carcinoma (with other high-risk subtypes of HPV such as 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 69).

Risk factors for the development of anal or perianal warts are: immunosuppression (iatrogenic on long-term steroids for connective...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Chin-Hong, P. V., & Palefsky, J. M. (2002). Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clinical Infectious Diseases, 35, 1127–1134.PubMedGoogle Scholar
  2. Longacre, T. A., Kong, C. S., & Welton, M. L. (2008). Diagnostic problems in anal pathology. Advances in Anatomic Pathology, 15, 263–278.PubMedGoogle Scholar
  3. Rock, B., Shah, K. V., & Farmer, E. R. (1992). A morphologic, pathologic, and virologic study of anogenital warts in men. Archives of Dermatology, 128, 495–500.PubMedGoogle Scholar
  4. Scholefield, J. H., Harris, D., & Radcliffe, A. (2011). Guidelines for management of anal intraepithelial neoplasia. Colorectal Disease, 13, 3–10.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Service d’Anatomie PathologiqueCentre Hospitalier et Universitaire du NordAmiensFrance
  2. 2.Faculté de Médecine Pierre et Marie Curie, Service d’Anatomie et Cytologie PathologiquesHôpital Saint-AntoineParisFrance