Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Neutropenic Colitis

  • Ann DriessenEmail author
Reference work entry


Agranulocytic colitis; Ileocaecal syndrome; Neutropenic enteropathy; Phlegmonous caecitis; Typhlitis


Neutropenic enterocolitis is an inflammatory and necrotizing process, predominantly involving the caecum, occurring in neutropenic patients. Because of its caecal localization, the disease is also named typhlitis, deriving from the Greek word typhlon, meaning caecum.

Neutropenic enterocolitis is a life-threatening disease for the first time described in children with leukemia in 1933. It is most commonly observed after chemotherapy for a hematological or a lymphoproliferative malignancy, but it may also found in relationship to a wide variety of solid tumors, e.g., colorectal, breast, lung, and ovarian cancer. It is also reported in patients with an acquired immunodeficiency syndrome (AIDS), aplastic anemia, cyclic neutropenia, after an autologous stem cell transplantation or in those, showing idiosyncratic drug reactions involving antibiotics or immunosuppressives....

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References and Further Reading

  1. Cloutier, R. L. (2009). Neutropenic enterocolitis. Emergency Medicine Clinics of North America, 27, 415–422.CrossRefGoogle Scholar
  2. Ebert, E. C., & Hagspiel, K. D. (2012). Gastrointestinal manifestations of leukemia. Journal of Gastroenterology and Hepatology, 27, 458–463.CrossRefGoogle Scholar
  3. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). Gastrointestinal pathology. An atlas and text (3rd ed., pp. 838–841). Philadelphia: Lippincott, Williams & Wilkins.Google Scholar
  4. Gil, L., Poplawski, D., Mol, A., Nowicki, A., Schneider, A., & Komarnicki, M. (2012). Neutropenic enterocolitis after high-dose chemotherapy and autologous stem cell transplantation: Incidence, risk factors, and outcome. Transplant Infectious Disease: An Official Journal of the Transplantation Society, 15(1), 1–7. doi:10.111/j.1399-3062.2012:0:1 7.CrossRefGoogle Scholar
  5. Ullery, B. W., Pieracci, F. M., Rodney, J. R., & Barie, P. S. (2009). Neutropenic enterocolitis. Surgical Infections, 10, 307–314.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyUniversity Hospital AntwerpEdegemBelgium
  2. 2.Maastricht University Medical CentreMaastrichtThe Netherlands