Collagenous colitis; Lymphocytic colitis
Microscopic colitis is an umbrella term for two major entities known as lymphocytic (LC) and collagenous colitis (CC). The term microscopic colitis (MC) describes a clinical pathological entity characterized by three elements: (a) a clinical history of chronic watery (non-bloody) diarrhea, (b) a normal or almost normal endoscopic appearance of the colon, and (c) a distinct histologic pattern. The latter can be either that of collagenous colitis (CC) or that of lymphocytic colitis. Therefore, the term microscopic colitis could be applied only from the endoscopic point of view in the presence of normal or almost normal endoscopic examination. Both LC and CC are clinically characterized by chronic watery diarrhea, while other conditions with normal endoscopy and abnormal histology may have other clinical characteristics. The pathogenesis is still not completely understood and probably multifactorial. It is suggested to represent...
References and Further Reading
- Langner C, Aust D, Ensari A, Villanacci V, Becheanu G, Miehlke S, Geboes K, Münch A; Working Group of Digestive Diseases of the European Society of Pathology (ESP) and the European Microscopic Colitis Group (EMCG) (2015) Histology of microscopic colitis-review with a practical approach for pathologists. Histopathology, 66(5), 613–626.Google Scholar