Microscopic colitis; Microscopic colitis with intraepithelial lymphocytosis
Lymphocytic colitis (LC) is characterized by a diffuse increase of intraepithelial lymphocytes (IELs) (>20 IELs per 100 epithelial cells) in the surface epithelium accompanied by an increase of lamina propria inflammatory cells. By definition, no subepithelial collagen deposition should be present. The diagnosis of LC should be made in conjunction with clinical, endoscopic, and histological findings. Patients typically present with chronic watery diarrhea with normal or near-normal endoscopy.
The incidence of LC is approximately 3.1 in 100,000.
It is common in middle-aged to older adults with a mean age of 51 years.
Female predominance is less in LC with nearly equal sex distribution.
There are reports that suggest nonuniform colonic involvement, with less inflammation in the left colon compared with the right colon.
Most patients respond to...
References and Further Reading
- Langner C, Aust D, Ensari A, Villanacci V, Becheanu G, Miehlke S, Geboes K, Münch A; Working Group of Digestive Diseases of the European Society of Pathology (ESP) and the European Microscopic Colitis Group (EMCG) (2015) Histology of microscopic colitis-review with a practical approach for pathologists. Histopathology, 66(5), 613–626.Google Scholar