Induction and Maintenance Agents

  • Adam CochraneEmail author
Living reference work entry
Part of the Organ and Tissue Transplantation book series (OTT)


Immunosuppression has increased the success of human heart transplant. There are specific patient groups that benefit from the use of induction therapy though the use of induction therapy has not shown universal benefit for all patients. Currently heart transplant centers employ dual or triple immunosuppression regimens with a calcineurin inhibitor as the base of the regimen and consideration given to antiproliferative agents or PSI/mTOR as the additional agent, with or without corticosteroids. The tolerability of agents can limit their use despite the therapeutic benefit, in addition to immunosuppression, toward renal sparing effects, viral sparing effects, or vasculopathy benefits. The choice of agents make individualization of immunosuppression possible based on a specific patient’s needs.


Maintenance immunosuppression Heart transplant induction PSI/mTOR antiviral properties PSI/mTOR CAV C2 monitoring Calcineurin inhibitors Antiproliferative agents 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Inova Fairfax HospitalFalls ChurchUSA

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