Metopic Suture Synostoses

Living reference work entry


“Metopic suture synostosis, which is called trigonocephaly, is mostly considered to be in the simple craniosynostosis group, among the anomalies of craniosynostosis types. The keel-shaped forehead, the narrowness of the frontotemporal area and the wideness of the parietal area, and the hyperteloric eye structure are the distinguishing properties.


  1. Alderman BW, Lammer EI, Ioshua SC, Cordero IF, Ouimette DR, Wilson MI, Ferguson SW (1988) An epidemiologic study of craniosynostosis Risk indicators for the occurrence of craniosynostosis in Colorado. Am J Epidemiol 128:431–438PubMedCrossRefPubMedCentralGoogle Scholar
  2. Alderman BW, Bradley CM, Greene C, Fernbach SK, Baron AE (1994) Increased risk of craniosynostosis with maternal cigarette smoking during pregnancy. Teratology 50:13–18PubMedCrossRefPubMedCentralGoogle Scholar
  3. Alderman BW, Zamudia S, Baron AE, Ioshua SC, Fernbach SK, Greene C, Mangione EI (1995) Increased risk of craniosynostosis with higher antenatal maternal altitude. Int J Epidemiol 24:420–426PubMedCrossRefPubMedCentralGoogle Scholar
  4. Alderman BW, Fernbach SK, Greene C, Mangione EI, Ferguson SW (1997) Diagnostic practice and the estimated prevalence of craniosynostosis in Colorado. Arch Pediatr Adolesc Med 151:159–164PubMedCrossRefPubMedCentralGoogle Scholar
  5. Anderson FM, Geiger L (1965) Craniosynostosis: a survey of 204 cases. J Neurosurg 22:229–240PubMedCrossRefPubMedCentralGoogle Scholar
  6. Arnaud E, Renier D, Marchac D (1995) Prognosis for mental function in scaphocephaly. J Neurosurg 83:476–479PubMedCrossRefPubMedCentralGoogle Scholar
  7. Aryan HE, Meltzer HS, Gerras GG, Iandial R, Levy ML (2004) Leptomeningeal cyst development after endoscopic craniosynostosis repair: case report. Neurosurgery 55:235–237, discussion 237–238PubMedCrossRefPubMedCentralGoogle Scholar
  8. Aryan HE, Iandial R, Ozgur BM, Hughes SA, Meltzer HS, Park MS, Levy ML (2005) Surgical correction of metopic synostosis. Childs Nerv Syst 23:392–398CrossRefGoogle Scholar
  9. Aypar E, Yildirim MS, Sert A, Ciftci I, Odabas D (2011) A girl with metopic synostosis and trisomy 13 mosaicism: case report and review of the literature. Am J Med Genet 155A:638–641PubMedCrossRefPubMedCentralGoogle Scholar
  10. Azimi C, Kennedy SI, Chitayat D, Chakraborty P, Clarke IT, Forrest C, Teebi AS (2003) Clinical and genetic aspects of trigonocephaly: a study of 25 cases. Am J Med Genet 117A:127–135PubMedCrossRefPubMedCentralGoogle Scholar
  11. Baumgartner IE, Teichgraeber IF, Waller AL, Grantcherova E, Gateno I, Xia I (2005) Microscopic approach to craniosynostosis. J Craniofac Surg 16:997–1005PubMedCrossRefPubMedCentralGoogle Scholar
  12. Becker PT, Engelhardt KF, Steinmann MF, Kane I (1997) Infant age, context, and family system influences on the interactive behavior of mothers of infants with mental delay. Res Nurs Health 20:39–50PubMedCrossRefPubMedCentralGoogle Scholar
  13. Bottero L, Lajeunie E, Arnaud E, Marchac D, Renier D (1998) Functional outcome after surgery for trigonocephaly. Plast Reconstr Surg 102:952–958, discussion 959PubMedCrossRefPubMedCentralGoogle Scholar
  14. Chu TW, Teebi AS, Gibson L, Breg WR, Yang-feng TL (1994) FISH diagnosis of partial trisomy 13 and tetrasomy 13 in a patient with severe trigonocephaly C phenotype. Am J Med Genet 52:92–96PubMedCrossRefPubMedCentralGoogle Scholar
  15. Cohen MM (1986) Syndromes with craniosynostosis. In: Cohen MM (ed) Craniosynostosis: diagnosis, evaluation and management. Raven, New York, pp 413–590Google Scholar
  16. Cohen MM (2005) Editorial: perspectives on craniosynostosis. Am J Med Genet A 136A:313–326PubMedCrossRefPubMedCentralGoogle Scholar
  17. Cohen MM, MacLean MC (2000) Craniosynostosis: diagnosis, evaluation, and management, 2nd edn. Oxford University Press, OxfordGoogle Scholar
  18. Collmann H, Sorensen N, Krauss I (1996) Consensus: trigonocephaly. Childs Nerv Syst 12:664–668PubMedCrossRefPubMedCentralGoogle Scholar
  19. Currarino G, Silverman FN (1960) Orbital hypotelorism, arhinecephaly and trigonocephaly. Radiology 74:206–217PubMedCrossRefPubMedCentralGoogle Scholar
  20. David LR, Proffer P, Hurstz WI, Glazier S, Argenta LC (2004) Spring-mediated cranial reshaping for craniosynostosis. J Craniofac Surg 15:810–816, discussion 817–818PubMedCrossRefPubMedCentralGoogle Scholar
  21. Davis C, Lauritzen CGK (2009) Frontobasal suture distraction corrects Hypotelorism in metopic synostosis. J Craniofac Surg 20:121–124PubMedCrossRefPubMedCentralGoogle Scholar
  22. Delashaw JB, Persing JA, Jane JA (1991) Cranial deformation in craniosynostosis. A new explanation. Neurosurg Clin N Am 2(3):611–620PubMedCrossRefPubMedCentralGoogle Scholar
  23. Denis D, Genitori L, Conrath I, Lena G, Choux M (1996) Ocularfindings in children operated on for plagiocephalyand trigonocephaly. Childs Nerv Syst 12:683–689PubMedCrossRefPubMedCentralGoogle Scholar
  24. Di Rocco F, Amaud E, Meyer P, Sainte-Rose C, Renier D (2009a) Focus session on the changing “epidemiology” of craniosynostosis (comparing two quinquennia: 1985–1989 and 2003–2007) and its impact on the daily clinical practice: a review from Necker Enfants Malades. Childs Nerv Syst 25:807–811PubMedCrossRefPubMedCentralGoogle Scholar
  25. Di Rocco F, Arnaud E, Renier D (2009b) Evolution in the frequency of nonsyndromic craniosynostosis. J Neurosurg Pediatr 4:21–25PubMedCrossRefPubMedCentralGoogle Scholar
  26. Dimopoulos VG, Machinis TG, Fountas KN, Robinson JS (2005) Head injury management algorithm as described in Hippocrates’ “peri ton en cephali traumaton”. Neurosurgery 57(6):1303–1305; discussion 1303–5PubMedCrossRefGoogle Scholar
  27. DiRocco VF, Ferrario A, Marchese E (1996) Metopic synostosis: in favour of a “simplified” surgical treatment. Childs Nerv Syst 12:654–663CrossRefGoogle Scholar
  28. Domeshek LP, Das RR, Van Aalst IA, Mukundan LS, Marcus IR (2011) Influence of metopic suture fusion associated with sagittal synostosis. J Craniofac Surg 22:77–83PubMedCrossRefGoogle Scholar
  29. Dominguez R, Sang K, Bender T, Girdany B (1981) Uncomplicated trigonocephaly: a radiographic affirmation of conservative therapy. Radiology 140:681–688PubMedCrossRefGoogle Scholar
  30. Eppley BL, Sadove AM (1994) Surgical correction of metopic suture synostosis. Clin Plast Surg 21:555–562PubMedGoogle Scholar
  31. Faro C, Chaoui R, Wegrzyn P, Levaillant IM, Benoit B, Nicolaides KH (2006) Metopic suture in fetuses with Apert syndrome at 22–27 weeks of gestation. Ultrasound Obstet Gynecol 27:28–33PubMedCrossRefGoogle Scholar
  32. Fearon A, Steinthal I (2002) The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children. Plast Reconstr Surg 109:2190–2196PubMedCrossRefGoogle Scholar
  33. Fearon I, Kolar IC, Munro IR (1996) Trigonocephaly-associated hypotelorism: is treatment necessary? Plast Reconstr Surg 97:503–509PubMedCrossRefGoogle Scholar
  34. Fisher DC, Kornrumpf BP, Couture D, Glazier SS, Argenta LC, David LR (2011) Increased incidence of metopic suture abnormalities in children with positional plagiocephaly. J Craniofac Surg 22:89–95PubMedCrossRefGoogle Scholar
  35. Friede H, Alberius P, Lilja I, Lauritzen C (1990) Trigonocephaly: clinical and cephalometric assessment of craniofacial morphology in operated and nontreated patients. Cleft Palate J 27:362–367, discussion 368PubMedGoogle Scholar
  36. Furuya Y, Edwards MS, Alpers CE, Tress BM, Norman D, Ousterhout DK (1984a) Computerized tomography of cranial sutures. 1. Comparison of suture anatomy in children and adults. J Neurosurg 61:53–58PubMedCrossRefGoogle Scholar
  37. Furuya Y, Edwards MS, Alpers CE, Tress BM, Norman D, Ousterhout DK (1984b) Computerized tomography of cranial sutures, part 2: abnormalities of sutures and skull deformity in craniosynostosis. J Neurosurg 61:59–70PubMedCrossRefGoogle Scholar
  38. Genitori L, Cavalheiro S, Lena G, Dollo C, Choux M (1991) Skull base in trigonocephaly. Pediatr Neurosurg 17:175–181PubMedCrossRefGoogle Scholar
  39. Goel A, Muzumdar D, Nitta I, Hongo K (2001) Plate and screw technique for advancement of the supraorbital bar in surgery for craniosynostosis: a preliminary technical report. Br J Neurosurg 15:251–253PubMedCrossRefGoogle Scholar
  40. Greenberg BM, Schneider SJ (2006) Trigonocephaly: surgical considerations and long term evaluation. J Craniofac Surg 17:528–535PubMedCrossRefGoogle Scholar
  41. Guimaraes-Ferreira I, Gewalli F, David L, Olsson R, Friede H, Lauritzen CG (2003) Spring mediated cranioplasty compared with the modified pi-plasty for sagittal synostosis. Scand J Plast Reconstr Surg Hand Surg 37:208–215PubMedCrossRefGoogle Scholar
  42. Guzman R, Looby JF, Schendel SA, Edwards MSB (2011) Fronto-orbital advancement using an en bloc frontal bone craniectomy. Neurosurgery 68(Suppl 1):68–74Google Scholar
  43. Haralick RM, Shapiro LG (1992) Computer and robot vision, vol 608. Addison-Lesley, New York, p 1516Google Scholar
  44. Havlik RI, Azurin DJ, Bartlett SP, Whitaker LA (1999) Analysis and treatment of severe trigonocephaly. Plast Reconstr Surg 103:381–390PubMedCrossRefGoogle Scholar
  45. Hilling DE, Mathijssen I, Vaandrager JM (2006) Aesthetic results of fronto-orbital correction in trigonocephaly. J Craniofac Surg 17:1167–1174PubMedCrossRefGoogle Scholar
  46. Hoffman HI, Mohr G (1976) Lateral canthal advancement of the supraorbital margin: a new corrective technique in the treatment of coronal synostosis. J Neurosurg 45:376–381PubMedCrossRefGoogle Scholar
  47. Hormozi AK, Shahverdiani R, Mohammadi HR, Zali A, Mofrad HRH (2011) Surgical treatment of metopic synostosis. J Craniofac Surg 22:261–265PubMedCrossRefGoogle Scholar
  48. Jane JA et al (2019) Surgery for craniosynostosis treatment & management.
  49. Jehee FS, Iohnson D, Alonso LG, Cavalcanti DP, de Sa Moreira E, Alberto FL, Kok P, Kim C, Wall SA, Iabs EW, Boyadjiev SA, Wilkie AO, Passos-Bueno MR (2005) Molecular screening for microdeletions at 9p22-p24 and 11q23- q24 in a large cohort of patients with trigonocephaly. Clin Genet 67:503–510PubMedCrossRefGoogle Scholar
  50. Jimenez DP, Barone CM (2007) Early treatment of anterior calvarial craniosynostosis using endoscopic-assisted minimally invasive techniques. Childs Nerv Syst 23:1411–1419PubMedCrossRefGoogle Scholar
  51. Jimenez DP, Barone CM (2010) Multiple-suture nonsyndromic craniosynostosis: early and effective management using endoscopic techniques. J Neurosurg Pediatr 5:223–231PubMedCrossRefPubMedCentralGoogle Scholar
  52. Kallen K (1999) Maternal smoking and craniosynostosis. Teratology 60:146–150PubMedCrossRefPubMedCentralGoogle Scholar
  53. Kapp-Simon KA (1998) Mental development and learning disorders in children with single suture craniosynostosis. Cleft Palate Craniofac J 35:197–203PubMedCrossRefGoogle Scholar
  54. Kapp-Simon KA, Figueroa A, Iocher CA, Schafer M (1993) Longitudinal assessment of mental development in infants with nonsyndromic craniosynostosis with and without cranial release and reconstruction. Plast Reconstr Surg 92:831–839. discussion 840–841PubMedCrossRefGoogle Scholar
  55. Kelleher MO, Murray DI, McGillivary A, Kamel MH, Allcut D, Earley MI (2007) Non-syndromic trigonocephaly: surgical decision making and long-term cosmetic results. Childs Nerv Syst 23:1285–1289PubMedCrossRefGoogle Scholar
  56. Keshavarzi S, Hayden MG, Ben-Haim S, Meltzer HS, Cohen SR, Levy ML (2009) Variations of endoscopic and open repair of metopic craniosynostosis. J Craniofac Surg 20:1439–1444PubMedCrossRefGoogle Scholar
  57. Kini U, Hurst JA, Byren IC, Wall SA, Johnson D, Wilkie AO (2010) Etiological heterogeneity and clinical characteristics of metopic synostosis: evidence from a tertiary craniofacial unit. Am J Med Genet 152A:1383–1389PubMedGoogle Scholar
  58. Kocabalkan O, Owman-Moll P, Sugawara Y, Eriede H, Lauritzen C (2000) Evaluation of a surgical technique for trigonocephaly. Scand J Plast Reconstr Surg Hand Surg 34:33–42PubMedCrossRefGoogle Scholar
  59. Koh KS, Kang MH, Yu SC, Park SH, Ra YS (2004) Treatment of nonsyndromic bilateral coronal synostosis using a multiple bone flap rotation-reposition technique. J Craniofac Surg 15:603–608PubMedCrossRefGoogle Scholar
  60. Kolar IC, Salter EM (1997) Preoperative anthropometric dysmorphology in metopic synostosis. Am J Phys Anthropol 103:341–351PubMedCrossRefGoogle Scholar
  61. Krajewski K, Ashley RK, Pung N, Wald S, Lazareff J, Kawamato HK, Bradley IP (2008) Successful blood conservation during craniosynostotic correction with dual therapy using Procrit and cell saver. J Craniofac Surg 19:101–105PubMedCrossRefPubMedCentralGoogle Scholar
  62. Kumar AV, Staffenberg DA, Petronio JA, Wood RI (1997) Bioabsorbable plates and screws in pediatric craniofacial surgery: a review of 22 cases. J Craniofac Surg 8:97–99PubMedCrossRefPubMedCentralGoogle Scholar
  63. Lajeunie E, Le Merrer M, Marchac D, Renier D (1998) Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients. Am J Med Genet 75:211–215PubMedCrossRefPubMedCentralGoogle Scholar
  64. Lajeunie E, Barcik U, Thorne IA, El Ghouzzi V, Bourgeois M, Renier D (2001) Craniosynostosis and fetal exposure to sodium valproate. J Neurosurg 95:778–782PubMedCrossRefPubMedCentralGoogle Scholar
  65. Lajeunie E, Crimmins DW, Arnaud E, Renier D (2005) Genetic considerations in nonsyndromic midline craniosynostoses: a study of twins and their families. J Neurosurg 103:353–356PubMedPubMedCentralGoogle Scholar
  66. Lauritzen C (1998) Spring mediated dynamic craniofacial reshaping: case report. Scand J Plast Reconstr Surg Hand Surg 32:331–338PubMedCrossRefPubMedCentralGoogle Scholar
  67. Lauritzen C, Davis C, Ivarson A, Sanger C, Hewitt TD (2008) The evolving role of springs in craniofacial surgery. The first 100 clinical cases. Plast Reconstr Surg 121:545–554PubMedCrossRefPubMedCentralGoogle Scholar
  68. Losken A, Williams IK, Burstein FD, Cohen SR, Hudgins R, Bovdston W, Reisner A, Simms C (2001) Outcome analysis for correction of single suture craniosynostosis using resorbable fixation. J Craniofac Surg 12:451–455PubMedCrossRefPubMedCentralGoogle Scholar
  69. Maltese G, Tarnow P, Lauritzen CG (2007) Spring-assisted correction of hypotelorism in metopic synostosis. Plast Reconstr Surg 119:977–984PubMedCrossRefPubMedCentralGoogle Scholar
  70. Marchac D (1978) Radical forehead remodeling for craniostenosis. Plast Reconstr Surg 61:823–835PubMedCrossRefPubMedCentralGoogle Scholar
  71. Marsh IL, Gurley IM, Kane AA (2005) Non-syndromic craniosynostosis. In: Mathes SI (ed) Plastic surgery, cilt 4, 2nd edn. Saunders, Philadelphia, pp 135–164Google Scholar
  72. Mathijssen IM, van Splunder I, Vermeij-Keers C, Pieterman H, de Iong TH, Mooney MP, Vaandrager IM (1999) Tracing craniosynostosis to its developmental stage through bone center displacement. J Craniofac Genet Dev Biol 19:57–63PubMedPubMedCentralGoogle Scholar
  73. Matson D (1968) Neurosurgery of infancy and childhood. Charles C Thomas, Springfield, pp 122–167Google Scholar
  74. McCarthy IG, Glasberg SB, Cutting CB, Epstein PJ, Grayson BH, Ruff G, Thorne CH, Wisotf I, Zide BM (1995) Twenty-year experience with early surgery for craniosynostosis, I. Isolated craniofacial synostosis: results and unsolved problems. Plast Reconstr Surg 96:272–283PubMedCrossRefPubMedCentralGoogle Scholar
  75. McCarthy IG, Bradley IP, Longaker MT (1996) Step expansion of the frontal bar: correction of Trigonocephaly. J Craniofac Surg 7:333–335PubMedCrossRefPubMedCentralGoogle Scholar
  76. McDonald-McGinn DM, Feret H, Nah HD, Bartlett SP, Whitaker LA, Zackai EH (2010) Metopic craniosynostosis due to mutations in GLI3: a novel association. Am J Med Genet 152A:1654–1660PubMedCrossRefPubMedCentralGoogle Scholar
  77. Mendonca DA, White N, West E, Dover S, Solanki G, Nishikawa H (2009) Is there a relationship between the severity of metopic synostosis and speech and language impairments? J Craniofac Surg 20:85–88; discussion 89PubMedCrossRefPubMedCentralGoogle Scholar
  78. Mutluer S (2013) Editorial on trigonocephaly. Childs Nerv Syst 29(12):2163PubMedCrossRefPubMedCentralGoogle Scholar
  79. Mutluer S, Songur E (1990) A new technique for correction of metopic suture synostosis. Childs Nerv Syst 6:317–321CrossRefGoogle Scholar
  80. Noetzel MI, Marsh IL, Palkes H, Gado M (1985) Hydrocephalus and mental retardation in craniosynostosis. J Pediatr 107:885–892PubMedCrossRefPubMedCentralGoogle Scholar
  81. Oh DY, Byeon IH (2002) Right angled Z-osteotomy in total cranial vault remodeling in sagittal synostosis. J Korean Soc Plast Reconstr Surg 29:348–351Google Scholar
  82. Oi S, Matsumoto S (1987) Trigonocephaly (metopic synostosis). Childs Nerv Syst 3:259–265PubMedCrossRefPubMedCentralGoogle Scholar
  83. Opitz IM, Iohnson RC, McCreadie SR, Smith DW (1969) The C syndrome of multiple congenital anomalies. Birth Defects Orig Artic Ser 5:161–166Google Scholar
  84. Ozlen F, Kafadar AM, Abuzayed B, Ulu MU, Isler C, Dashti R, Erdincler P (2011) Surgical treatment of trigonocephaly: technique and long term results in 48 cases. J Neurosurg Pediatr 7:300–310PubMedCrossRefPubMedCentralGoogle Scholar
  85. Paige KT, Cohen SR, Simms C, Burstein FD, Hudgins R, Boydston W (2003) Predicting the risk of reoperation in metopic synostosis: a quantitative CT scan analysis. Ann Plast Surg 51:167–172PubMedCrossRefPubMedCentralGoogle Scholar
  86. Paik H, Byeon IH (2010) Anterior two-thirds calvarial remodelling: operative technique for the correction of metopic synostosis in toddlers. J Plast Reconstr Aesthet Surg 63:36–41PubMedCrossRefPubMedCentralGoogle Scholar
  87. Persing JA, Jane JA, Shaffrey M (1989) Virchow and the pathogenesis of craniosynostosis: a translation of his original work. Plast Reconstr Surg 83(4):738–742PubMedCrossRefPubMedCentralGoogle Scholar
  88. Posnick IC, Lin KY, Chen P, Armstrong D (1994) Metopic synostosis: quantitative assessment of presenting deformity and surgical results based on CT scans. Plast Reconstr Surg 93:16–24PubMedCrossRefPubMedCentralGoogle Scholar
  89. Ramos Fuentes PI, Nicholson L, Scott CI Jr (1994) Phenotypic variability in the Baller-Gerold syndrome: report of a mildly affected patient and review of the literature. Eur J Pediatr 153:483–487PubMedCrossRefPubMedCentralGoogle Scholar
  90. Rangayyan MR (2005) Biomedical image analysis. CRC Press, New YorkGoogle Scholar
  91. Renier D, Brunet L, Marchac D (1987) IQ and Craniostenosis: evolution in treated and untreated cases. In: Marchac D (ed) Craniofacial surgery: first international congress of the international society of craniomaxillofacial surgery. Springer, Berlin, pp 114–117CrossRefGoogle Scholar
  92. Richtsmeier IT, Deleon VB, Lele SR (2002) The promise of geometric morphometrics. Am J Phys Anthropol 35:63–91PubMedCrossRefPubMedCentralGoogle Scholar
  93. Rodt T, Schlesinger A, Schramm A, Diensthuber M, Rittierodt M, Krauss IK (2007) 3D visualization and simulation of frontoorbital advancement in metopic synostosis. Childs Nerv Syst 23:1313–1317PubMedCrossRefPubMedCentralGoogle Scholar
  94. Ruiz-Correa S, Sze RW, Starr IR, Lin HT, Speltz ML, Cunningham ML, Hing AV (2006) New scaphocephaly severity indices of sagittal craniosynostosis: a comparative study with cranial index quantifications. Cleft Palate Craniofac J 43:211–221PubMedCrossRefPubMedCentralGoogle Scholar
  95. Ruiz-Correa S, Starr IR, Lin HI, Kapp-Simon KA, Cunningham ML, Speltz ML (2007) Severity of skull malformation is unrelated to neurobehavioral dysfunction in infants with sagittal synostosis. Cleft Palate Craniofac J 44:548–554PubMedCrossRefPubMedCentralGoogle Scholar
  96. Ruiz-Correa S, Starr IR, Lin HI, Kapp-Simon IQX, Sze RW, Ellenbogen RG, Speltz ML, Cunningham ML (2008) New severity indices for quantifying single-suture metopic craniosynostosis. Neurosurgery 63:318–324PubMedPubMedCentralCrossRefGoogle Scholar
  97. Sadove AM, Kalsbeck IE, Eppley BL, Iaved T (1990) Modifications in the surgical correction of trigonocephaly. Plast Reconstr Surg 85:853–858PubMedCrossRefPubMedCentralGoogle Scholar
  98. Sargent C, Burn I, Baraitser M, Pembrey ME (1985) Trigonocephaly and the Opitz C syndrome. J Med Genet 2:39–45CrossRefGoogle Scholar
  99. Say B, Meyer I (1981) Familial trigonocephaly associated with short stature and developmental delay. Am J Dis Child 135:711–712PubMedPubMedCentralGoogle Scholar
  100. Schaap C, Schrander-Strumpel CT, Fryns IP (1992) Opitz-C syndrome: on the nosology of mental retardation and trigonocephaly. Genet Couns 3:209–215PubMedPubMedCentralGoogle Scholar
  101. Selber I, Reid RR, Gershman B, Sonnad SS, Sutton LN, Whitaker LA, Bartlett SP (2007) Evolution of operative techniques for the treatment of single-suture metopic synostosis. Ann Plast Surg 59:6–13PubMedCrossRefPubMedCentralGoogle Scholar
  102. Selber I, Reid RR, Chike-Obi CI, Sutton LN, Zackai EH, McDonald-McGinn D, Sonnad SS, Whitaker LA, Bartlett SP (2008) The changing epidemiologic spectrum of single-suture synostoses. Plast Reconstr Surg 122:527–533PubMedCrossRefPubMedCentralGoogle Scholar
  103. Shillito J Jr, Matson DD (1968) Craniosynostosis: a review of 519 surgical patients. Pediatrics 41:829–853PubMedPubMedCentralGoogle Scholar
  104. Shimoji T, Shimabukuro S, Sugama S, Ochiai Y (2002) Mild trigonocephaly with clinical symptoms: analysis of surgical results in 65 patients. Childs Nerv Syst 18:215–224PubMedCrossRefPubMedCentralGoogle Scholar
  105. Shipster C, Hearst D, Dockrell IE, Kilby E, Hayward R (2002) Speech and language skills and cognitive functioning in children with Apert syndrome: a pilot study. Int J Lang Commun Disord 37:325–343CrossRefGoogle Scholar
  106. Shuper A, Merlob P, Grunebaum M, Reisner SH (1985) The incidence of isolated craniosynostosis in the newborn infant. Am J Dis Child 139:85–86PubMedPubMedCentralGoogle Scholar
  107. Sidoti IE, Ieffrey LM, Marty-Grames L, Noetzel MI (1996) Long-term studies of metopic synostosis: frequency of cognitive impairment and behavioral disturbances. Plast Reconstr Surg 97:276–281PubMedCrossRefPubMedCentralGoogle Scholar
  108. Singh RP, Dhariwal D, Bhujel N, Shaikh Z, Davies P, Nishikawa H, Solanki G, Dover MS (2010) Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis. Br J Oral Maxillofac Surg 48:438–442PubMedCrossRefPubMedCentralGoogle Scholar
  109. Smartt IM, Karmacharya I, Gannon PH, Ong G, Jackson O, Bartlett SP, Poser RD, Kirschner RE (2005) Repair of the immature and mature craniofacial skeleton with a carbonated calcium phosphate cement: assessment of biocompatibility, osteoconductivity, and remodeling capacity. Plast Reconstr Surg 115:1642–1650PubMedCrossRefPubMedCentralGoogle Scholar
  110. Songür E, Mutluer S (1991) A new approach for trigonocephaly correction. In: Caronni EP (ed) Craniofacial surgery 3. Bologna, Monduzzi EditoreGoogle Scholar
  111. Songür E, Mutluer S, Güla T, Görken C (1999) A modified fixation method in supraorbital bar advancement. J Craniofac Surg 10:198–202PubMedCrossRefPubMedCentralGoogle Scholar
  112. Speltz ML, Morton K, Goodell EW, Clarren SK (1993) Psychological functioning of children with craniofacial anomalies and their mothers: follow-up from late infancy to school entry. Cleft Palate Craniofac J 30:482–489PubMedCrossRefGoogle Scholar
  113. Speltz ML, Kapp-Simon KA, Cunningham M, Marsh I, Dawson G (2004) Single-suture craniosynostosis: a review of neurobehavioral research and theory. J Pediatr Psychol 29:651–668PubMedCrossRefGoogle Scholar
  114. Starr IR, Lin HI, Ruiz-Correa S, Cunningham ML, Ellenbogen RG, Collett BR, Kapp-Simon KA, Speltz ML (2010) Little evidence of association between severity of trigonocephaly and cognitive development in infants with single-suture metopic synostosis. Neurosurgery 67:408–415. discussion 415–416PubMedPubMedCentralCrossRefGoogle Scholar
  115. Steinbok P, Heran N, Hicdonmez T, Cochrane DD, Price A (2004) Minimizing blood transfusions in the surgical correction of coronal and metopic craniosynostosis. Childs Nerv Syst 20:445–452PubMedGoogle Scholar
  116. Terner IS, Travieso R, Lee SS, Forte AJ, Patel A, Persing JA (2011) Combined metopic and sagittal craniosynostosis: is it worse than sagittal synostosis alone? Neurosurg Focus 31:E2PubMedCrossRefGoogle Scholar
  117. Tokumaru AM, Barkovich AI, Ciricillo SP, Edwards MS (1996) Skull base and calvarial deformities: association with intracranial changes in craniofacial syndromes. AJNR Am J Neuroradiol 17:619–630PubMedGoogle Scholar
  118. Travan L, Pecile V, Pertz M, Pabretto A, Brovedani P, Demarini S, Opitz IM (2011) Opitz trigonocephaly syndrome presenting with sudden unexplained death in the operating room: a case report. J Med Case Reports 5:222PubMedCentralCrossRefPubMedGoogle Scholar
  119. Tubbs RS, Elton S, Blount IP, Oakes WI (2001) Preliminary observations on the association between simple metopic ridging in children without trigonocephaly and the Chiari 1 malformation. Pediatr Neurosurg 35:136–139PubMedCrossRefGoogle Scholar
  120. Unal S, Celik PC, Soy D, Ceylaner S, Ceylaner G (2009) A boy with trisomy 13 presenting with a subtle clinical picture and metopic synostosis. Am J Med Genet 149A:1608–1609PubMedCrossRefPubMedCentralGoogle Scholar
  121. van der Meulen J (2012) Metopic synostosis. Childs Nerv Syst 28:1359–1367PubMedPubMedCentralCrossRefGoogle Scholar
  122. van der Meulen I, Nazir PR, Mathijssen IM, van Adrichem LN, Ongkosuwito E, Stolk-Lieiferink SA, Vaandrager MI (2008) Bitemporal depressions after cranioplasty for trigonocephaly: a long-term evaluation of (supra) orbital growth in 92 patients. J Craniofac Surg 19:72–79PubMedCrossRefPubMedCentralGoogle Scholar
  123. van der Meulen J, van der Hulst R, van Adrichem L, Arnaud E, Chin-Shong D, Duncan C, Habets E, Hinojosa I, Mathijssen I, May P, Morritt D, Nishikawa H, Noons P, Richardson D, Wall S, van der Vlugt I, Renier D (2009) The increase of metopic synostosis: a pan-European observation. J Craniofac Surg 20:283–286PubMedCrossRefPubMedCentralGoogle Scholar
  124. Vu HL, Panchal I, Parke EE, Levine NS, Francel P (2001) The timing of physiologic closure of the metopic suture: a review of 159 patients using reconstructed 3D CT scans of the craniofacial region. J Craniofac Surg 12:527–532PubMedCrossRefGoogle Scholar
  125. Warschausky S, Angobaldo I, Remnan D, Buchman S, Muraszko KM, Azengart A (2005) Early development of infants with untreated metopic craniosynostosis. Plast Reconstr Surg 115:1518–1523PubMedCrossRefGoogle Scholar
  126. Weinzweig I, Kirschner RE, Farley A, Reiss P, Hunter I, Whitaker LA, Bartlett SP (2003) Metopic synostosis: defining fine temporal sequence of normal suture fusion and differentiating it from synostosis on the basis of computed tomography images. Plast Reconstr Surg 112:1211–1218PubMedCrossRefGoogle Scholar
  127. Winston K, Beatty RM, Fischer EG (1983) Consequences of dural defects acquired in infancy. J Neurosurg 59:839–846PubMedCrossRefGoogle Scholar
  128. Zumpano MP, Carson BS, Marsh IL, Vanderkolk CA, Richtsmeier IT (1999) Three-dimensional morphological analysis of isolated metopic synostosis. Anat Rec 256:177–188PubMedCrossRefGoogle Scholar

Authors and Affiliations

  1. 1.Private Gazi HospitalIzmirTurkey

Section editors and affiliations

  • Concezio Di Rocco
    • 1
  • Federico Di Rocco
    • 2
    • 3
  1. 1.Pediatric NeurosurgeryInternational Neuroscience InstituteHannoverGermany
  2. 2.Service de Neurochirurgie PédiatriqueHôpital Femme Mère Enfant-GHELyonFrance
  3. 3.Centre de Référence Craniosténoses, Université de LyonLyonFrance

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