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Monogenic and Polygenic Contributions to Hypertension

  • Julie R. Ingelfinger
Reference work entry

Abstract

This chapter provides an overview of the genetics of hypertension, reviewing what is known about rare mendelian forms of hypertension, which can be explained by mutations in single genes, as well as the genetics of primary hypertension. Different approaches that allow discovery of new aspects of the genetics of primary hypertension such as candidate gene approaches, linkage studies, and genome-wide association studies are discussed. It is hoped that this chapter will provide a concise primer for reading the literature in the area of genetics and hypertension. The chapter also provides guidance on patient evaluation and approach.

Keywords

Monogenic Polygenic Familial hypertension Mendelian Low-renin hypertension 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julie R. Ingelfinger
    • 1
  1. 1.Division of NephrologyMassGeneral for Children at Massachusetts General Hospital, Harvard Medical School, Department of PediatricsBostonUSA

Section editors and affiliations

  • Julie R. Ingelfinger
    • 1
  1. 1.Pediatric Nephrology UnitMassGeneral Hospital for Children at MGH, Harvard Medical SchoolBostonUSA

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