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Hypertensive Models and Their Relevance to Pediatric Hypertension

  • Julie R. Ingelfinger
Reference work entry

Abstract

Much of what we know about the physiology of blood pressure (BP) regulation and the pathogenesis and treatment of human hypertension has been derived from studies in other animal species. This chapter presents a variety of models of experimental hypertension with the intent of providing a background for the interested reader. Many models explore normal and abnormal physiology without genetic manipulation but rather with the use of surgery, infusion of medications, alterations in diet, and application of stressful conditions. In other models, inbreeding or genetic manipulation is used to produce increased (or decreased) BP. The many models available should be considered both for carrying out research and for evaluating published studies.

Keywords

Experimental hypertension Animal models Transgenic Knockout Renovascular hypertension Consomic Congenic 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julie R. Ingelfinger
    • 1
  1. 1.Division of NephrologyMassGeneral for Children at Massachusetts General Hospital, Harvard Medical School, Department of PediatricsBostonUSA

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