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Secondary Forms of Hypertension in Children: Overview

  • Sheena SharmaEmail author
  • Kevin E. Meyers
  • Smitha R. Vidi
Reference work entry

Abstract

Blood pressure is a very important vital sign providing significant information into the health of a child. Sustained elevated readings require further evaluation to determine if a child has primary or secondary hypertension. Secondary forms of hypertension are more common in younger children than in adolescents, and often, in those presenting with very elevated blood pressure readings. After careful clinical evaluation, most causes of secondary hypertension in children are readily identifiable. The causes for secondary hypertension are noted in this chapter and discussed in depth elsewhere in this text. In this chapter, we also discuss the clinical challenge of trying to identify a secondary cause for hypertension in a child or adolescent when none is obvious. Improved methods for predicting secondary hypertension in asymptomatic children are needed to guide cost-effective work-up and would also reduce the likelihood of missing a treatable cause of hypertension.

Keywords

Secondary Hypertension Renovascular Parenchymal Coarctation of aorta Endocrine 

References

  1. Amin R, Anthony L, Somers V et al (2008) Growth velocity predicts recurrence of sleep-disordered breathing 1 year after adenotonsillectomy. Am J Respir Crit Care Med 177:654–659PubMedPubMedCentralGoogle Scholar
  2. Apostolidou MT, Alexopoulos EI, Damani E et al (2008) Absence of blood pressure, metabolic, and inflammatory marker changes after adenotonsillectomy for sleep apnea in Greek children. Pediatr Pulmonol 43:550–560PubMedGoogle Scholar
  3. Arnold AC, Okamoto LE, Dierdich A et al (2013) Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study. Neurology 80(21):1927–1933PubMedPubMedCentralGoogle Scholar
  4. Baracco R, Kapur G, Mattoo T et al (2012) Prediction of primary vs secondary hypertension in children. J Clin Hypertens (Greenwich) 14:316–321Google Scholar
  5. Barletta GM, Flynn J, Mitsnefes M, Samuels J, Friedman LA, Ng D, Cox C, Poffenbarger T, Warady B, Furth S (2014) Heart rate and blood pressure variability in children with chronic kidney disease: a report from the CKiD study. Pediatr Nephrol 29(6):1059–1065PubMedPubMedCentralGoogle Scholar
  6. Bowers K, Liu G, Wang P et al (2011) Birth weight, postnatal weight change, and risk for high blood pressure among Chinese children. Pediatrics 127:e1272–e1279PubMedPubMedCentralGoogle Scholar
  7. Chen X, Wang Y (2008) Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 117(25):3171–3180PubMedPubMedCentralGoogle Scholar
  8. Chiarelli F, Trotta D, Verrotti A, Mohn A (2002) Treatment of hypertension and microalbuminuria in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 3:113–124PubMedGoogle Scholar
  9. Cohen G, Jeffery H, Lagercrantz H, Katz-Salamon M (2010) Long-term reprogramming of cardiovascular function in infants of active smokers. Hypertension 55:722–728PubMedGoogle Scholar
  10. Constantin E, McGregor CD, Cote V, Brouillette RT (2008) Pulse rate and pulse rate variability decrease after adenotonsillectomy for obstructive sleep apnea. Pediatr Pulmonol 43:498–504PubMedGoogle Scholar
  11. Darcan S, Goksen D, Mir S et al (2006) Alterations of blood pressure in type 1 diabetic children and adolescents. Pediatr Nephrol 21:672–676PubMedGoogle Scholar
  12. Dell KM, Kaplan BS (2000) Hypertension with lower extremity traumatic amputation. Clin Pediatr (Phila) 39:417–419Google Scholar
  13. DeVries WH, Kruse RW (1998) Is there a relationship between hypertension and lower-extremity contracture release in cerebral palsy? Am J Orthop (Belle Mead NJ) 27:421–422Google Scholar
  14. Dorresteijn JA, Visseren FL, Spiering W (2012) Mechanisms linking obesity to hypertension. Obes Rev 13:17–26PubMedGoogle Scholar
  15. Dost A, Klinkert C, Kapellen T et al (2008) Arterial hypertension determined by ambulatory blood pressure profiles: contribution to microalbuminuria risk in a multicenter investigation in 2,105 children and adolescents with type 1 diabetes. Diabetes Care 31:720–725PubMedGoogle Scholar
  16. Eison TM, Ault BH, Jones DP et al (2011) Post-streptococcal glomerulonephritis in children: clinical features and pathogenesis. Pediatr Nephrol 26(2):165–180PubMedGoogle Scholar
  17. Ellis D, Moritz ML, Vats A, Janosky JE (2004) Antihypertensive and renoprotective efficacy and safety of losartan. A long-term study in children with renal disorders. Am J Hypertens 17:928–935PubMedGoogle Scholar
  18. Ettinger LM, Freeman K, DiMartino-Nardi JR, Flynn JT (2005) Microalbuminuria and abnormal ambulatory blood pressure in adolescents with type 2 diabetes mellitus. J Pediatr 147:67–73PubMedGoogle Scholar
  19. Fathallah-Shaykh SA, Flynn JT, Pierce CB et al (2015) Progression of pediatric CKD of nonglomerular origin in the CKiD cohort. Clin J Am Soc Nephrol 10(4):571–57791PubMedPubMedCentralGoogle Scholar
  20. Filler G, Yasin A, Kesarwani P, Garg AX, Lindsay R, Sharma AP (2011) Big mother or small baby: which predicts hypertension? J Clin Hypertens (Greenwich) 13:35–41Google Scholar
  21. Flynn J (2002) Differentiation between primary and secondary hypertension in children using ambulatory blood pressure monitoring. Pediatrics 110(1 Pt 1):89–93PubMedGoogle Scholar
  22. Flynn JT, Meyers KE, Neto JP et al (2008a) Efficacy and safety of the Angiotensin receptor blocker valsartan in children with hypertension age 1 to 5 years. Hypertension 52:222–228PubMedGoogle Scholar
  23. Flynn JT, Mitsnefes M, Pierce C et al (2008b) Blood pressure in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children study. Hypertension 52:631–637PubMedPubMedCentralGoogle Scholar
  24. Flynn J, Zhang Y, Solar-Yohay S et al (2012) Clinical and demographic characteristics of children with hypertension. Hypertension 60(4):1047–1054PubMedGoogle Scholar
  25. Furth SL, Cole SR, Moxey-Mims M et al (2006) Design and methods of the Chronic Kidney Disease in Children (CKiD) prospective cohort study. Clin J Am Soc Nephrol 1:1006–1115PubMedPubMedCentralGoogle Scholar
  26. Gambelunghe A, Sallsten G, Borne Y et al (2016) Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort. Environ Res 149:157–16392PubMedGoogle Scholar
  27. Gomes RS, Quirino IG, Pereira RM et al (2011) Primary versus secondary hypertension in children followed up at an outpatient tertiary unit. Pediatr Nephrol 26:441–447PubMedGoogle Scholar
  28. Goto M, Hoxha N, Osman R, Dell KM (2010) The renin-angiotensin system and hypertension in autosomal recessive polycystic kidney disease. Pediatr Nephrol 25:2449–2457PubMedGoogle Scholar
  29. Graham LM, Zelenock GB, Erlandson EE, Coran AG, Lindenauer SM, Stanley JC (1979) Abdominal aortic coarctation and segmental hypoplasia. Surgery 86:519–529PubMedGoogle Scholar
  30. Green R, Gu X, Kline-Rogers E, Froehlich J, Mace P, Gray B, Katzen B, Olin J, Gornik HL, Cahill AM, Meyers KE (2016) Differences between the pediatric and adult presentation of fibromuscular dysplasia: results from the US Registry. Pediatr Nephrol 31(4):641–650PubMedPubMedCentralGoogle Scholar
  31. Grossman E, Messerli FH (1995) High blood pressure. A side effect of drugs, poisons, and food. Arch Intern Med 155:450–460PubMedGoogle Scholar
  32. Gupta-Malhotra M, Banker A, Shete S et al (2015) Essential hypertension vs. secondary hypertension among children. Am J Hypertens 28(1):73–80PubMedGoogle Scholar
  33. Hadtstein C, Schaefer F (2008) Hypertension in children with chronic kidney disease: pathophysiology and management. Pediatr Nephrol 23:363–371PubMedGoogle Scholar
  34. Hamdani G, Nehus EJ, Hanevold CD, Sebestyen Van Sickle J, Woroniecki R, Wenderfer SE, Hooper DK, Blowey D, Wilson A, Warady BA, Mitsnefes MM (2016) Ambulatory blood pressure, left ventricular hypertrophy, and allograft function in children and young adults after kidney transplantation. TransplantationGoogle Scholar
  35. Hammerness PG, Karampahtsis C, Babalola R, Alexander ME (2015) Attention-deficit/hyperactivity disorder treatment: what are the long-term cardiovascular risks? Expert Opin Drug Saf 14(4):543–551PubMedGoogle Scholar
  36. Hansen ML, Gunn PW, Kaelber DC (2007) Underdiagnosis of hypertension in children and adolescents. JAMA 298:874–879PubMedPubMedCentralGoogle Scholar
  37. Harrison WM, McGrath PJ, Stewart JW, Quitkin F (1989) MAOIs and hypertensive crises: the role of OTC drugs. J Clin Psychiatry 50:64–65PubMedGoogle Scholar
  38. Heij HA, Ekkelkamp S, Vos A (1992) Hypertension associated with skeletal traction in children. Eur J Pediatr 151:543–545PubMedGoogle Scholar
  39. Hindmarsh PC, Bryan S, Geary MP, Cole TJ (2010) Effects of current size, postnatal growth, and birth size on blood pressure in early childhood. Pediatrics 126:e1507–e1513PubMedGoogle Scholar
  40. Hocker B, Weber LT, Feneberg R et al (2009) Prospective, randomized trial on late steroid withdrawal in pediatric renal transplant recipients under cyclosporine microemulsion and mycophenolate mofetil. Transplantation 87:934–941PubMedGoogle Scholar
  41. Hung CS, Chang LY, Sui HH, Chao T, Van YH, Lo FS (2006) Clinical and laboratory findings at initial diagnosis in pediatric Graves’ disease in Taiwan. Acta Paediatr Taiwan 47:77–82PubMedGoogle Scholar
  42. Huxley RR, Shiell AW, Law CM (2000) The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature. J Hypertens 18:815–831PubMedGoogle Scholar
  43. Ing FF, Goldberg B, Siegel DH, Trachtman H, Bierman FZ (1995) Arterial stents in the management of neurofibromatosis and renovascular hypertension in a pediatric patient: case report of a new treatment modality. Cardiovasc Intervent Radiol 18:414–418PubMedPubMedCentralGoogle Scholar
  44. Jalal DI, Smits G, Johnson RJ, Chonchol M (2010) Increase fructose associates with elevated blood pressure. J Am Soc Nephrol 21:1543–1549PubMedPubMedCentralGoogle Scholar
  45. Kapur G, Ahmed M, Pan C, Mitsnefes M, Chiang M, Mattoo TK (2010) Secondary hypertension in overweight and stage 1 hypertensive children: a Midwest Pediatric Nephrology Consortium report. J Clin Hypertens (Greenwich) 12:34–39Google Scholar
  46. Keijzer-Veen MG, Dulger A, Dekker FW, Nauta J, van der Heijden BJ (2010) Very preterm birth is a risk factor for increased systolic blood pressure at a young adult age. Pediatr Nephrol 25:509–516PubMedGoogle Scholar
  47. Kerr GS (1995) Takayasu’s arteritis. Rheum Dis Clin North Am 21(4):1041–1058PubMedGoogle Scholar
  48. Khaw KT, Peart WS (1982) Blood pressure and contraceptive use. Br Med J (Clin Res Ed) 285:403–40799PubMedCentralGoogle Scholar
  49. Kirton A, Crone M, Benseler S et al (2013) Fibromuscular dysplasia and childhood stroke. Brain 136:1846–1856PubMedGoogle Scholar
  50. Koskimies O (1982) Arterial hypertension developing 10 years after radiotherapy for Wilms’s tumour. Br Med J (Clin Res Ed) 285:996–998Google Scholar
  51. Kramer AM, van Stralen KJ, Jager KJ, Schaefer F, Verrina E, Seeman T, Lewis MA, Boehm M, Simonetti GD, Novljan G, Groothoff JW (2011) Demographics of blood pressure and hypertension in children on renal replacement therapy in Europe. Kidney Int 80(10):1092–1098PubMedGoogle Scholar
  52. Lau KK, Stoffman JM, Williams S et al (2007) Neonatal renal vein thrombosis: review of the English-language literature between 1992 and 2006. Pediatrics 120:31278–31284Google Scholar
  53. Malik U, Raizada V (2015) Some Aspects of the Renin-Angiotensin-System in Hemodialysis Patients. Kidney Blood Press Res 40(6):614–622PubMedPubMedCentralGoogle Scholar
  54. Mann KD, Tennant PW, Parker L, Unwin NC, Pearce MS (2011) The relatively small contribution of birth weight to blood pressure at age 49–51 years in the Newcastle Thousand Families Study. J Hypertens 29:1077–1084PubMedGoogle Scholar
  55. Marcus CL (2001) Sleep-disordered breathing in children. Am J Respir Crit Care Med 164:16–30PubMedGoogle Scholar
  56. Mathew AJ, Goel R, Kumar S, Danda D (2016) Childhood-onset Takayasu arteritis: an update. Int J Rheum Dis 19(2):116–126PubMedGoogle Scholar
  57. Matteucci MC, Chinali M, Rinelli G, Wühl E, Zurowska A, Charbit M, Pongiglione G, Schaefer F, ESCAPE Trial Group (2013) Change in cardiac geometry and function in CKD children during strict BP control: a randomized study. Clin J Am Soc Nephrol 8(2):203–210PubMedGoogle Scholar
  58. McLaren CA, Roebuck DJ (2003) Interventional radiology for renovascular hypertension in children. Tech Vasc Interv Radiol 6:150–157PubMedGoogle Scholar
  59. McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150:640–644, 4 e1PubMedPubMedCentralGoogle Scholar
  60. Michael M, Brewer ED, Goldstein SL (2004) Blood volume monitoring to achieve target weight in pediatric hemodialysis patients. Pediatr Nephrol 19:432–437PubMedGoogle Scholar
  61. Mitsnefes MM (2004) Hypertension and end-organ damage in pediatric renal transplantation. Pediatr Transplant 8:394–399PubMedGoogle Scholar
  62. Mitsnefes M, Stablein D (2005) Hypertension in pediatric patients on long-term dialysis: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Am J Kidney Dis 45:309–315PubMedGoogle Scholar
  63. Muntner P, He J, Cutler JA, Wildman RP, Whelton PK (2004) Trends in blood pressure among children and adolescents. JAMA 291:2107–2113PubMedPubMedCentralGoogle Scholar
  64. Nakagawa TA, Sartori SC, Morris A, Schneider DS (2004) Intravenous nicardipine for treatment of postcoarctectomy hypertension in children. Pediatr Cardiol 25:26–30PubMedGoogle Scholar
  65. Neild GH (2009) What do we know about chronic renal failure in young adults? II. Adult outcome of pediatric renal disease. Pediatr Nephrol 24:1921–1928PubMedGoogle Scholar
  66. Ng DK, Wong JC, Chan CH, Leung LC, Leung SY (2010) Ambulatory blood pressure before and after adenotonsillectomy in children with obstructive sleep apnea. Sleep Med 11:721–725PubMedGoogle Scholar
  67. Nicolaidou P, Georgouli H, Matsinos Y, Psychou F, Messaritaki A, Gourgiotis D, Zeis P (2003) Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. Pediatr Int 45(1):35–38PubMedGoogle Scholar
  68. Olin JW, Gornik HL, Bacharach JM et al (2014) Fibromuscular dysplasia: state of the science and critical unanswered questions: a scientific statement from the American Heart Association. Circulation 129(9):1048–1078PubMedGoogle Scholar
  69. Onat T, Zeren E (1969) Coarctation of the abdominal aorta. Review of 91 cases. Cardiologia 54:140–157PubMedGoogle Scholar
  70. Pacak K (2007) Preoperative management of the pheochromocytoma patient. J Clin Endocrinol Metab 92:4069–4079PubMedGoogle Scholar
  71. Pack AI, Gislason T (2009) Obstructive sleep apnea and cardiovascular disease: a perspective and future directions. Prog Cardiovasc Dis 51:434–451PubMedGoogle Scholar
  72. Parker ED, Sinaiko AR, Kharbanda EO et al (2016) Change in weight status and development of hypertension. Pediatrics 137(3), e20151662PubMedPubMedCentralGoogle Scholar
  73. Patel N, Walker N (2016) Clinical assessment of hypertension in children. Clin HypertensGoogle Scholar
  74. Pludowski P, Litwin M, Niemirska A et al (2009) Accelerated skeletal maturation in children with primary hypertension. Hypertension 54:1234–1239PubMedGoogle Scholar
  75. Power RE, Calleary JG, Hickey DP (2001) Pre-transplant bilateral native nephrectomy for medically refractory hypertension. Ir Med J 94:214–216PubMedGoogle Scholar
  76. Quante M, Wang R, Weng J et al (2015) Childhood Adenotonsillectomy Trial (CHAT). The Effect of adenotonsillectomy for childhood sleep apnea on cardiometabolic measures. Sleep 38(9):1395–1403PubMedPubMedCentralGoogle Scholar
  77. Rabchevsky AG, Kitzman PH (2011) Latest Approaches for the Treatment of Spasticity and Autonomic Dysreflexia in Chronic Spinal Cord Injury. Neurotherapeutics 8(2):274–282PubMedPubMedCentralGoogle Scholar
  78. Raile K, Galler A, Hofer S et al (2007) Diabetic nephropathy in 27,805 children, adolescents, and adults with type 1 diabetes: effect of diabetes duration, A1C, hypertension, dyslipidemia, diabetes onset, and sex. Diabetes Care 30:2523–2528PubMedGoogle Scholar
  79. Reddy BV, Chapman AB (2016) The spectrum of autosomal dominant polycystic kidney disease in children and adolescents. Pediatr NephrolGoogle Scholar
  80. Rouine-Rapp K, Mello DM, Hanley FL, Mohan Reddy V, Soifer S (2003) Effect of enalaprilat on postoperative hypertension after surgical repair of coarctation of the aorta. Pediatr Crit Care Med 4:357Google Scholar
  81. Ryan CM, Bradley TD (2005) Pathogenesis of obstructive sleep apnea. J Appl Physiol 99:2440–2450PubMedGoogle Scholar
  82. Schrier RW, Abebe KZ, Perrone RD et al (2014) Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med 371(24):2255–2266PubMedPubMedCentralGoogle Scholar
  83. Schwartz GJ, Furth SL (2007) Glomerular filtration rate measurement and estimation in chronic kidney disease. Pediatr Nephrol 22:1839–1848PubMedGoogle Scholar
  84. Seeman T, Palyzova D, Dusek J et al (2005) Reduced nocturnal blood pressure dip and sustained nighttime hypertension are specific markers of secondary hypertension. J Pediatr 147(3):366–371PubMedGoogle Scholar
  85. Sethna CB, Kaplan BS, Cahill AM, Velazquez OC, Meyers KE (2008) Idiopathic mid-aortic syndrome in children. Pediatr Nephrol 23:1135–1142PubMedGoogle Scholar
  86. Shahinfar S, Cano F, Soffer BA et al (2005) A double-blind, dose–response study of losartan in hypertensive children. Am J Hypertens 18:183–190PubMedGoogle Scholar
  87. Shokeir AA, Osman Y, Ali-El-Dein B, El-Husseini A, El-Mekresh M, Shehab-El-Din AB (2005) Surgical complications in live-donor pediatric and adolescent renal transplantation: study of risk factors. Pediatr Transplant 9:33–38PubMedGoogle Scholar
  88. Shroff R, Roebuck DJ, Gordon I et al (2006) Angioplasty for renovascular hypertension in children: 20-year experience. Pediatrics 118:268–275PubMedGoogle Scholar
  89. Siassi B, Klyman G, Emmanouilides GC (1970) Hypoplasia of the abdominal aorta associated with the rubella syndrome. Am J Dis Child 120:476–479PubMedGoogle Scholar
  90. Simonetti GD, von Vigier RO, Konrad M, Rizzi M, Fossali E, Bianchetti MG (2006) Candesartan cilexetil in children with hypertension or proteinuria: preliminary data. Pediatr Nephrol 21:1480–1482PubMedGoogle Scholar
  91. Singh C, Jones H, Copeman H, Sinha MD (2016) Fifteen-minute consultation: the child with systemic arterial hypertension. Arch Dis Child Educ Pract EdGoogle Scholar
  92. Singhal V, Schwenk WF, Kumar S (2007) Evaluation and management of childhood and adolescent obesity. Mayo Clin Proc 82:1258–1264PubMedGoogle Scholar
  93. Sorof J, Daniels S (2002) Obesity hypertension in children: a problem of epidemic proportions. Hypertension 40:441–447Google Scholar
  94. Sozen H, Dalgic A, Karakayali H et al (2006) Renal transplantation in children. Transplant Proc 38:426–429PubMedGoogle Scholar
  95. Teigen CL, Mitchell SE, Venbrux AC, Christenson MJ, McLean RH (1992) Segmental renal artery embolization for treatment of pediatric renovascular hypertension. J Vasc Interv Radiol 3:111–117PubMedGoogle Scholar
  96. Textor SC, Townsend RR (2008) Hypertension. NephSAP 7:63Google Scholar
  97. Tirosh A, Afek A, Rudich A et al (2010) Progression of normotensive adolescents to hypertensive adults: a study of 26,980 teenagers. Hypertension 56(2):203–209PubMedGoogle Scholar
  98. Towbin RB, Pelchovitz DJ, Cahill AM et al (2007) Cutting balloon angioplasty in children with resistant renal artery stenosis. J Vasc Interv Radiol 18:663–669PubMedGoogle Scholar
  99. Trachtman HM, Gipson D (2012) Pediatric nephrology. NephSAP 11(1):12–18Google Scholar
  100. Trasande L, Sathyanarayana S, Spanier AJ et al (2013) Urinary phthalates are associated with higher blood pressure in childhood. J Pediatr 163(3):747–753PubMedPubMedCentralGoogle Scholar
  101. Tullus K (2015) Management of the renovascular disease in children with Takayasu arteritis. Pediatr Nephrol 30(8):1213–1216PubMedGoogle Scholar
  102. Tullus K, Brennan E, Hamilton G et al (2008) Renovascular hypertension in children. Lancet 371:1453–1463PubMedGoogle Scholar
  103. Ugur MB, Dogan SM, Sogut A et al (2008) Effect of adenoidectomy and/or tonsillectomy on cardiac functions in children with obstructive sleep apnea. ORL J Otorhinolaryngol Relat Spec 70:202–208PubMedGoogle Scholar
  104. Vanderheyden T, Kumar S, Fisk NM (2003) Fetal renal impairment. Semin Neonatol 8:279–289PubMedGoogle Scholar
  105. VanDeVoorde RG, Barletta GM, Chand DH et al (2007) Blood pressure control in pediatric hemodialysis: the Midwest Pediatric Nephrology Consortium Study. Pediatr Nephrol 22:547–553PubMedGoogle Scholar
  106. Vidi SR, Meyers KEC (2013) Secondary forms of hypertension in children and adolescents. In: Flynn JT, Inglefinger JR, Portman RJ (eds) Pediatric hypertension, vol 3. Springer, New York, pp 309–321Google Scholar
  107. Viera AJ, Neutze DM (2010) Diagnosis of secondary hypertension: an age-based approach. Am Fam Physician 82:1471–1478PubMedGoogle Scholar
  108. Vlahandonis A, Walter LM, Horne RS (2012) Does treatment of SDB in children improve cardiovascular outcome? Sleep Med Rev 17:75–85PubMedGoogle Scholar
  109. von Vigier RO, Zberg PM, Teuffel O, Bianchetti MG (2000) Preliminary experience with the angiotensin II receptor antagonist irbesartan in chronic kidney disease. Eur J Pediatr 159:590–593Google Scholar
  110. Warady BA, Abraham AG, Schwartz GJ, Wong CS, Muñoz A, Betoko A, Mitsnefes M, Kaskel F, Greenbaum LA, Mak RH, Flynn J, Moxey-Mims MM, Furth S (2015) Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort. Am J Kidney Dis 65(6):878–888PubMedPubMedCentralGoogle Scholar
  111. Wilson AC, Greenbaum LA, Barletta GM et al (2010) High prevalence of the metabolic syndrome and associated left ventricular hypertrophy in pediatric renal transplant recipients. Pediatr Transplant 14:52–60PubMedGoogle Scholar
  112. Maycock W (1937) Congenital stenosis of the abdominal aorta. Am Heart J 13:633–646Google Scholar
  113. Wu H, Liao Q, Chillrud SN et al (2016) Environmental Exposure to. Health Risk Assessment and its Associations with Hypertension and Impaired Kidney Function. Sci Rep, CadmiumGoogle Scholar
  114. Wuhl E, Trivelli A, Picca S et al (2009) Strict blood-pressure control and progression of renal failure in children. N Engl J Med 361:1639–1650PubMedGoogle Scholar
  115. Zimmerman D (1999) Fetal and neonatal hyperthyroidism. Thyroid 9:727–733PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sheena Sharma
    • 1
    Email author
  • Kevin E. Meyers
    • 1
  • Smitha R. Vidi
    • 2
  1. 1.Division of Nephrology, Department of PediatricsThe Children’s Hospital of Philadelphia, and Perelman School of Medicine, University of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of NephrologyChildren’s Health Specialty Center DallasDallasUSA

Section editors and affiliations

  • Joseph T. Flynn
    • 1
    • 2
  1. 1.Division of NephrologySeattle Children’s HospitalSeattleUSA
  2. 2.Department of PediatricsUniversity of Washington School of MedicineSeattleUSA

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