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Primary Hypertension in Children

  • Gaurav KapurEmail author
  • Tej K. Mattoo
Reference work entry

Abstract

Hypertension in children is not as common as in adults and its prevalence in the pediatric population is about 3–4%. Recent reports have highlighted an increasing prevalence of childhood hypertension, likely due to childhood obesity. Given the global burden of hypertension, identification and management of primary hypertension is beneficial to the individual child and has important implications for society as well, particularly since tracking studies have established that adult primary hypertension has its antecedents during childhood. Studies on the pathophysiology of primary hypertension in children are limited; however, evidence suggests that the proposed multifactorial and complex genetic, environmental, and biological interactions involved in the development of hypertension in adults provide a basis to understand hypertension in children as well. In comparison to younger children who mostly have secondary hypertension, primary hypertension is much more common in adolescents. Primary hypertension is diagnosed in children after a selective workup to rule out any underlying secondary causes. Early identification and management of elevated BP in the pediatric population is important to decrease the risks for end-organ injury in both the pediatric and adult population.

Keywords

Primary hypertension Children Hypertension Pathophysiology Risk factors Obesity End-organ damage 

References

  1. Acosta AA, Samuels JA, Portman RJ, Redwine KM (2012) Prevalence of persistent prehypertension in adolescents. J Pediatr 160(5):757–761PubMedGoogle Scholar
  2. Adams HR, Szilagyi PG, Gebhardt L, Lande MB (2010) Learning and attention problems among children with pediatric primary hypertension. Pediatrics 126(6):e1425–e1429PubMedPubMedCentralGoogle Scholar
  3. Akahoshi M, Soda M, Carter RL, Nakashima E, Shimaoka K, Seto S, Yano K (1996) Correlation between systolic blood pressure and physical development in adolescence. Am J Epidemiol 144(1):51–58PubMedGoogle Scholar
  4. Andersen LB, Riddoch C, Kriemler S, Hills AP (2011) Physical activity and cardiovascular risk factors in children. Br J Sports Med 45(11):871–876PubMedGoogle Scholar
  5. Antal M, Regoly-Merei A, Nagy K, Greiner E, Biro L, Domonkos A, Balajti A, Szorad I, Szabo C, Mozsary E (2004) Representative study for the evaluation of age- and gender-specific anthropometric parameters and blood pressure in an adolescent Hungarian population. Ann Nutr Metab 48(5):307–313PubMedGoogle Scholar
  6. Assadi F (2008) Relation of left ventricular hypertrophy to microalbuminuria and C-reactive protein in children and adolescents with essential hypertension. Pediatr Cardiol 29(3):580–584Google Scholar
  7. Aviv A, Aviv H (1997) Reflections on telomeres, growth, aging, and essential hypertension. Hypertension 29(5):1067–1072PubMedGoogle Scholar
  8. Ayer JG, Harmer JA, Nakhla S, Xuan W, Ng MK, Raitakari OT, Marks GB, Celermajer DS (2009) HDL-cholesterol, blood pressure, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children. Arterioscler Thromb Vasc Biol 29(6):943–949PubMedGoogle Scholar
  9. Baracco R, Kapur G, Mattoo T, Jain A, Valentini R, Ahmed M, Thomas R (2012) Prediction of primary vs secondary hypertension in children. J Clin Hypertens (Greenwich) 14(5):316–321Google Scholar
  10. Barker DJ (1992) The fetal origins of adult hypertension. J Hypertens Suppl 10 (7):S39–44PubMedGoogle Scholar
  11. Barnoya J, Glantz SA (2005) Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 111(20):2684–2698PubMedGoogle Scholar
  12. Beckett LA, Rosner B, Roche AF, Guo S (1992) Serial changes in blood pressure from adolescence into adulthood. Am J Epidemiol 135(10):1166–1177PubMedGoogle Scholar
  13. Bender J, Bonilla-Felix MA, Portman RJ (2004) Epidemiology of hypertension. In: Avner E, Harmon WE, Niaudet P (eds) Pediatric nephrology. Lippincott Williams and Wilkins, Philadelphia, pp 1125–1152Google Scholar
  14. Berenson GS, Mcmann CA, Voors AW (1980) Cardiovascular risk factors in children: the early natural history of atherosclerosis and essential hypertension. Oxford University Press, New YorkGoogle Scholar
  15. Berenson GS, Chen W, Dasmahapatra P, Fernandez C, Giles T, Xu J, Srinivasan SR (2011) Stimulus response of blood pressure in black and white young individuals helps explain racial divergence in adult cardiovascular disease: the Bogalusa Heart Study. J Am Soc Hypertens 5(4):230–238PubMedPubMedCentralGoogle Scholar
  16. Brady TM, Solomon BS, Neu AM, Siberry GK, Parekh RS (2010) Patient-, provider-, and clinic-level predictors of unrecognized elevated blood pressure in children. Pediatrics 125(6):e1286–e1293PubMedGoogle Scholar
  17. Brenner BM, Garcia DL, Anderson S (1988) Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1(4 Pt 1):335–347PubMedGoogle Scholar
  18. Brewer ED (2009) Evaluation of hypertension in childhood diseases. In: Avner ED, Harmon W, Niaudet P, Yoshikawa N (eds) Pediatric nephrology. Springer, Berlin, pp 1519–1540Google Scholar
  19. Bucher BS, Ferrarini A, Weber N, Bullo M, Bianchetti MG, Simonetti GD (2013) Primary hypertension in childhood. Curr Hypertens Rep 15(5):444–452PubMedGoogle Scholar
  20. Bunnell RE, Agaku IT, Arrazola RA, Apelberg BJ, Caraballo RS, Corey CG, Coleman BN, Dube SR, King BA (2015) Intentions to smoke cigarettes among never-smoking US middle and high school electronic cigarette users: National Youth Tobacco Survey, 2011–2013. Nicotine Tob Res 17(2):228–235PubMedGoogle Scholar
  21. Cao ZQ, Zhu L, Zhang T, Wu L, Wang Y (2012) Blood pressure and obesity among adolescents: a school-based population study in China. Am J Hypertens 25(5):576–582PubMedGoogle Scholar
  22. Chae CU, Lee RT, Rifai N, Ridker PM (2001) Blood pressure and inflammation in apparently healthy men. Hypertension 38(3):399–403PubMedGoogle Scholar
  23. Chen X, Wang Y (2008) Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 117(25):3171–3180PubMedPubMedCentralGoogle Scholar
  24. Chon H, Gaillard CA, van der Meijden BB, Dijstelbloem HM, Kraaijenhagen RJ, van Leenen D, Holstege FC, Joles JA, Bluyssen HA, Koomans HA, Braam B (2004) Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment. Hypertension 43(5):947–951PubMedGoogle Scholar
  25. Collins RT 2nd, Alpert BS (2009) Pre-hypertension and hypertension in pediatrics: don’t let the statistics hide the pathology. J Pediatr 155(2):165–169PubMedGoogle Scholar
  26. Coppo M, Bandinelli M, Berni A, Galastri S, Abbate R, Poggesi L, Marra F, Gensini GF, Boddi M (2011) Ang II Upregulation of the T-lymphocyte renin-angiotensin system is amplified by low-grade inflammation in human hypertension. Am J Hypertens 24(6):716–723PubMedGoogle Scholar
  27. Cornoni-Huntley J, LaCroix AZ, Havlik RJ (1989) Race and sex differentials in the impact of hypertension in the United States. The National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med 149(4):780–788PubMedGoogle Scholar
  28. Cruickshank JK, Jackson SH, Beevers DG, Bannan LT, Beevers M, Stewart VL (1985) Similarity of blood pressure in blacks, whites and Asians in England: the Birmingham Factory Study. J Hypertens 3(4):365–371PubMedGoogle Scholar
  29. Daniels SR, Lipman MJ, Burke MJ, Loggie JM (1991) The prevalence of retinal vascular abnormalities in children and adolescents with essential hypertension. Am J Ophthalmol 111(2):205–208Google Scholar
  30. Daniels SR, Kimball TR, Morrison JA, Khoury P, Meyer RA (1995) Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular disease. Am J Cardiol 76(10):699–701PubMedGoogle Scholar
  31. Dasgupta K, O’Loughlin J, Chen S, Karp I, Paradis G, Tremblay J, Hamet P, Pilote L (2006) Emergence of sex differences in prevalence of high systolic blood pressure: analysis of a longitudinal adolescent cohort. Circulation 114(24):2663–2670PubMedGoogle Scholar
  32. de Onis M, Blossner M, Borghi E (2010) Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 92(5):1257–1264PubMedGoogle Scholar
  33. de Rezende DF, Scarpelli RA, de Souza GF, da Costa JO, Scarpelli AM, Scarpelli PA, de Carvalho GB, D’Agostini HM, Pedrosa JC (2003) Prevalence of systemic hypertension in students aged 7 to 14 years in the municipality of Barbacena, in the State of Minas Gerais, in 1999. Arq Bras Cardiol 81(4):381–386, 375–380PubMedGoogle Scholar
  34. Diabetes Genetics Initiative of Broad Institute of Harvard, MIT LU, Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Bostrom K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjogren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316(5829):1331–1336Google Scholar
  35. Din-Dzietham R, Liu Y, Bielo MV, Shamsa F (2007) High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation 116(13):1488–1496Google Scholar
  36. Eaton SB, Konner M, Shostak M (1988) Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective. Am J Med 84(4):739–749PubMedGoogle Scholar
  37. Egan BM, Zhao Y, Axon RN (2010) US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. JAMA 303(20):2043–2050PubMedGoogle Scholar
  38. Ekelund U, Luan J, Sherar LB, Esliger DW, Griew P, Cooper A, International Children’s Accelerometry Database C (2012) Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents. JAMA 307(7):704–712PubMedPubMedCentralGoogle Scholar
  39. Elliott P, Stamler J, Nichols R, Dyer AR, Stamler R, Kesteloot H, Marmot M (1996) Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group. BMJ 312(7041):1249–1253PubMedPubMedCentralGoogle Scholar
  40. Falkner B (2010) Hypertension in children and adolescents: epidemiology and natural history. Pediatr Nephrol 25(7):1219–1224PubMedGoogle Scholar
  41. Farsalinos K, Cibella F, Caponnetto P, Campagna D, Morjaria JB, Battaglia E, Caruso M, Russo C, Polosa R (2016) Effect of continuous smoking reduction and abstinence on blood pressure and heart rate in smokers switching to electronic cigarettes. Intern Emerg Med 11(1):85–94PubMedPubMedCentralGoogle Scholar
  42. Feig DI, Johnson RJ (2003) Hyperuricemia in childhood primary hypertension. Hypertension 42(3):247–252PubMedPubMedCentralGoogle Scholar
  43. Flack JM, Gardin JM, Yunis C, Liu K (1999) Static and pulsatile blood pressure correlates of left ventricular structure and function in black and white young adults: the CARDIA study. Am Heart J 138(5 Pt 1):856–864PubMedGoogle Scholar
  44. Flack JM, Peters R, Mehra VC, Nasser SA (2002) Hypertension in special populations. Cardiol Clin 20(2):303–319, viiPubMedGoogle Scholar
  45. Flynn JT (2002) Differentiation between primary and secondary hypertension in children using ambulatory blood pressure monitoring. Pediatrics 110(1 Pt 1):89–93PubMedGoogle Scholar
  46. Flynn JT (2011) Ambulatory blood pressure monitoring in children: imperfect yet essential. Pediatr Nephrol 26(12):2089–2094PubMedGoogle Scholar
  47. Flynn J (2013) The changing face of pediatric hypertension in the era of the childhood obesity epidemic. Pediatr Nephrol 28(7):1059–1066PubMedGoogle Scholar
  48. Flynn JT, Falkner BE (2009) Should the current approach to the evaluation and treatment of high blood pressure in children be changed? J Pediatr 155(2):157–158PubMedGoogle Scholar
  49. Flynn E, Flavin A (2012) General practitioner’s reported use of clinical guidelines for hypertension and ambulatory blood pressure. Ir Med J 105(3):89–91PubMedGoogle Scholar
  50. Flynn JT, Urbina EM (2012) Pediatric ambulatory blood pressure monitoring: indications and interpretations. J Clin Hypertens (Greenwich) 14 (6):372–382PubMedGoogle Scholar
  51. Flynn JT, Daniels SR, Hayman LL, Maahs DM, McCrindle BW, Mitsnefes M, Zachariah JP, Urbina EM, American Heart Association Atherosclerosis, Hypertension, Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young (2014) Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association. Hypertension 63(5):1116–1135PubMedPubMedCentralGoogle Scholar
  52. Genovesi S, Giussani M, Pieruzzi F, Vigorita F, Arcovio C, Cavuto S, Stella A (2005) Results of blood pressure screening in a population of school-aged children in the province of Milan: role of overweight. J Hypertens 23(3):493–497Google Scholar
  53. Flynn JT, Kaelber DC, Baker-Smith CM et al (2017) Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140(3):e20171904Google Scholar
  54. Gong M, Hubner N (2006) Molecular genetics of human hypertension. Clin Sci (Lond) 110(3):315–326Google Scholar
  55. Gopinath B, Baur LA, Hardy LL, Kifley A, Rose KA, Wong TY, Mitchell P (2012) Relationship between a range of sedentary behaviours and blood pressure during early adolescence. J Hum Hypertens 26(6):350–356PubMedGoogle Scholar
  56. Gutin B, Basch C, Shea S, Contento I, DeLozier M, Rips J, Irigoyen M, Zybert P (1990) Blood pressure, fitness, and fatness in 5- and 6-year-old children. JAMA 264(9):1123–1127PubMedGoogle Scholar
  57. Halbach SM, Hamman R, Yonekawa K, Hanevold C (2016) Utility of ambulatory blood pressure monitoring in the evaluation of elevated clinic blood pressures in children. J Am Soc Hypertens 10(5):406–412PubMedGoogle Scholar
  58. Halldorsson TI, Gunnarsdottir I, Birgisdottir BE, Gudnason V, Aspelund T, Thorsdottir I (2011) Childhood growth and adult hypertension in a population of high birth weight. Hypertension 58(1):8–15PubMedGoogle Scholar
  59. Hanevold CD, Pollock JS, Harshfield GA (2008) Racial differences in microalbumin excretion in healthy adolescents. Hypertension 51(2):334–338PubMedGoogle Scholar
  60. Hansen ML, Gunn PW, Kaelber DC (2007) Underdiagnosis of hypertension in children and adolescents. JAMA 298(8):874–879PubMedGoogle Scholar
  61. Harrap SB, Tzourio C, Cambien F, Poirier O, Raoux S, Chalmers J, Chapman N, Colman S, Leguennec S, MacMahon S, Neal B, Ohkubo T, Woodward M, PROGRESS Collaborative Group (2003) The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition. Hypertension 42(3):297–303PubMedGoogle Scholar
  62. Harris KC, Benoit G, Dionne J, Feber J, Cloutier L, Zarnke KB, Padwal RS, Rabi DM, Fournier A, Force CGT (2016) Hypertension Canada’s 2016 Canadian hypertension education program guidelines for blood pressure measurement, diagnosis, and assessment of risk of pediatric hypertension. Can J Cardiol 32(5):589–597PubMedGoogle Scholar
  63. Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ, Thabet SR, Vinh A, Weyand CM (2011) Inflammation, immunity, and hypertension. Hypertension 57(2):132–140PubMedGoogle Scholar
  64. Harshfield GA, Alpert BS, Pulliam DA, Somes GW, Wilson DK (1994) Ambulatory blood pressure recordings in children and adolescents. Pediatrics 94(2 Pt 1):180–184PubMedGoogle Scholar
  65. He FJ, Marrero NM, Macgregor GA (2008) Salt and blood pressure in children and adolescents. J Hum Hypertens 22(1):4–11PubMedGoogle Scholar
  66. Hofman A, Hazebroek A, Valkenburg HA (1983) A randomized trial of sodium intake and blood pressure in newborn infants. JAMA 250(3):370–373PubMedGoogle Scholar
  67. Hollenberg N, Adams DF, Solomon H, Chenitz WR, Burger BM, Abrams HL (1975) Renal vascular tone in essential and secondary hypertension: hemodynamic and angiographic responses to vasodilators. Medicine (Baltimore) 54(1):29–44Google Scholar
  68. Hornsby JL, Mongan PF, Taylor AT, Treiber FA (1991) ‘White coat’ hypertension in children. J Fam Pract 33(6):617–623PubMedGoogle Scholar
  69. Intengan HD, Schiffrin EL (2001) Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38(3 Pt 2):581–587PubMedGoogle Scholar
  70. Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ, Mein CA, Onipinla A, Shaw-Hawkins S, Zhang Y, Davey Smith G, Day IN, Lawlor DA, Goodall AH, Cardiogenics C, Fowkes FG, Abecasis GR, Elliott P, Gateva V, Global BC, Braund PS, Burton PR, Nelson CP, Tobin MD, van der Harst P, Glorioso N, Neuvrith H, Salvi E, Staessen JA, Stucchi A, Devos N, Jeunemaitre X, Plouin PF, Tichet J, Juhanson P, Org E, Putku M, Sober S, Veldre G, Viigimaa M, Levinsson A, Rosengren A, Thelle DS, Hastie CE, Hedner T, Lee WK, Melander O, Wahlstrand B, Hardy R, Wong A, Cooper JA, Palmen J, Chen L, Stewart AF, Wells GA, Westra HJ, Wolfs MG, Clarke R, Franzosi MG, Goel A, Hamsten A, Lathrop M, Peden JF, Seedorf U, Watkins H, Ouwehand WH, Sambrook J, Stephens J, Casas JP, Drenos F, Holmes MV, Kivimaki M, Shah S, Shah T, Talmud PJ, Whittaker J, Wallace C, Delles C, Laan M, Kuh D, Humphries SE, Nyberg F, Cusi D, Roberts R, Newton-Cheh C, Franke L, Stanton AV, Dominiczak AF, Farrall M, Hingorani AD, Samani NJ, Caulfield MJ, Munroe PB (2011) Blood pressure loci identified with a gene-centric array. Am J Hum Genet 89(6):688–700PubMedPubMedCentralGoogle Scholar
  71. Julius S, Quadir H, Gajendragadhkar S (1979) Hyperkinetic state: a precursor of hypertension? A longitudinal study of borderline hypertension. In: Gross F, Strasser T (eds) Mild hypertension: natural history and management. Pittman, London, pp 116–126Google Scholar
  72. Julius S, Krause L, Schork NJ, Mejia AD, Jones KA, van de Ven C, Johnson EH, Sekkarie MA, Kjeldsen SE, Petrin J et al (1991) Hyperkinetic borderline hypertension in Tecumseh, Michigan. J Hypertens 9(1):77–84Google Scholar
  73. Jung FF, Ingelfinger JR (1993) Hypertension in childhood and adolescence. Pediatr Rev 14(5):169–179PubMedGoogle Scholar
  74. Kaplan NM (2009). Primary hypertension: pathogenesis. In: Kaplan NM, Victor RG, editors. Kaplan's clinical hypertension. 10th ed. Philadelphia: Lippincott-Williams and Wilkins; p. 42–107Google Scholar
  75. Kapur G (2013) What do I need to know to start ambulatory blood pressure monitoring for children with hypertension? Available at http://www2.aap.org/sections/nephrology/NephrologyNewsletterSpring2013.pdf
  76. Kapur G, Baracco R (2013) Evaluation of hypertension in children. Curr Hypertens Rep 15(5):433–443PubMedGoogle Scholar
  77. Kapur G, Ahmed M, Pan C, Mitsnefes M, Chiang M, Mattoo TK (2010) Secondary hypertension in overweight and stage 1 hypertensive children: a Midwest Pediatric Nephrology Consortium report. J Clin Hypertens (Greenwich) 12(1):34–39Google Scholar
  78. Kardas P, Kufelnicka M, Herczynski D (2005) Prevalence of arterial hypertension in children aged 9–14 years, residents of the city of Lodz. Kardiol Pol 62(3):211–216, discussion 216–217PubMedGoogle Scholar
  79. Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakayama T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H (2008) High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Hum Mol Genet 17(4):617–627PubMedGoogle Scholar
  80. Katz SH, Hediger ML, Schall JI, Bowers EJ, Barker WF, Aurand S, Eveleth PB, Gruskin AB, Parks JS (1980) Blood pressure, growth and maturation from childhood through adolescence. Mixed longitudinal analyses of the Philadelphia Blood Pressure Project. Hypertension 2(4 Pt 2):55–69PubMedGoogle Scholar
  81. Kavey RE, Kveselis DA, Atallah N, Smith FC (2007) White coat hypertension in childhood: evidence for end-organ effect. J Pediatr 150(5):491–497Google Scholar
  82. Kivimaki M, Lawlor DA, Smith GD, Elovainio M, Jokela M, Keltikangas-Jarvinen L, Vahtera J, Taittonen L, Juonala M, Viikari JS, Raitakari OT (2008) Association of age at menarche with cardiovascular risk factors, vascular structure, and function in adulthood: the Cardiovascular Risk in Young Finns study. Am J Clin Nutr 87(6):1876–1882PubMedGoogle Scholar
  83. Koch VH, Furusawa EA, Saito MI, Colli A, Ignes EC, Okay Y, Mion Junior D (1999) White coat hypertension in adolescents. Clin Nephrol 52(5):297–303PubMedGoogle Scholar
  84. Koivukoski L, Fisher SA, Kanninen T, Lewis CM, von Wowern F, Hunt S, Kardia SL, Levy D, Perola M, Rankinen T, Rao DC, Rice T, Thiel BA, Melander O (2004) Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3. Hum Mol Genet 13(19):2325–2332PubMedGoogle Scholar
  85. Korner PI, Bobik A, Angus JJ (1992) Are cardiac and vascular “amplifiers” both necessary for the development of hypertension? Kidney Int Suppl 37:S38–S44PubMedGoogle Scholar
  86. Kulaga Z, Litwin M, Tkaczyk M, Palczewska I, Zajaczkowska M, Zwolinska D, Krynicki T, Wasilewska A, Moczulska A, Morawiec-Knysak A, Barwicka K, Grajda A, Gurzkowska B, Napieralska E, Pan H (2011) Polish 2010 growth references for school-aged children and adolescents. Eur J Pediatr 170(5):599–609PubMedGoogle Scholar
  87. Kunes J, Kadlecova M, Vaneckova I, Zicha J (2012) Critical developmental periods in the pathogenesis of hypertension. Physiol Res 61(Suppl 1):S9–S17PubMedGoogle Scholar
  88. Kupferman JC, Lande MB, Adams HR, Pavlakis SG (2013) Primary hypertension and neurocognitive and executive functioning in school-age children. Pediatr Nephrol 28(3):401–408PubMedGoogle Scholar
  89. Lande MB, Kaczorowski JM, Auinger P, Schwartz GJ, Weitzman M (2003) Elevated blood pressure and decreased cognitive function among school-age children and adolescents in the United States. J Pediatr 143(6):720–724Google Scholar
  90. Lande MB, Meagher CC, Fisher SG, Belani P, Wang H, Rashid M (2008) Left ventricular mass index in children with white coat hypertension. J Pediatr 153(1):50–54PubMedPubMedCentralGoogle Scholar
  91. Lauer RM, Clarke WR (1989) Childhood risk factors for high adult blood pressure: the Muscatine Study. Pediatrics 84(4):633–641PubMedGoogle Scholar
  92. Lehman BJ, Taylor SE, Kiefe CI, Seeman TE (2009) Relationship of early life stress and psychological functioning to blood pressure in the CARDIA study. Health Psychol 28(3):338–346PubMedPubMedCentralGoogle Scholar
  93. Lever AF, Harrap SB (1992) Essential hypertension: a disorder of growth with origins in childhood? J Hypertens 10(2):101–120PubMedGoogle Scholar
  94. Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, Vasan RS, Mitchell GF (2007) Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet 8(Suppl 1):S3PubMedPubMedCentralGoogle Scholar
  95. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Kottgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM (2009) Genome-wide association study of blood pressure and hypertension. Nat Genet 41(6):677–687PubMedPubMedCentralGoogle Scholar
  96. Litwin M, Sladowska J, Antoniewicz J, Niemirska A, Wierzbicka A, Daszkowska J, Wawer ZT, Janas R, Grenda R (2007) Metabolic abnormalities, insulin resistance, and metabolic syndrome in children with primary hypertension. Am J Hypertens 20(8):875–882PubMedGoogle Scholar
  97. Litwin M, Michalkiewicz J, Niemirska A, Gackowska L, Kubiszewska I, Wierzbicka A, Wawer ZT, Janas R (2010) Inflammatory activation in children with primary hypertension. Pediatr Nephrol 25(9):1711–1718PubMedGoogle Scholar
  98. Litwin M, Michalkiewicz J, Gackowska L (2013a) Primary hypertension in children and adolescents is an immuno-metabolic disease with hemodynamic consequences. Curr Hypertens Rep 15(4):331–339PubMedPubMedCentralGoogle Scholar
  99. Litwin M, Michalkiewicz J, Trojanek J, Niemirska A, Wierzbicka A, Szalecki M (2013b) Altered genes profile of renin-angiotensin system, immune system, and adipokines receptors in leukocytes of children with primary hypertension. Hypertension 61(2):431–436PubMedGoogle Scholar
  100. Liu W, Zhao W, Chase GA (2004) Genome scan meta-analysis for hypertension. Am J Hypertens 17(12 Pt 1):1100–1106PubMedGoogle Scholar
  101. Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR (1999) Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatr 134(6):668–674PubMedGoogle Scholar
  102. Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, Staessen JA (2005) Prevalence, persistence, and clinical significance of masked hypertension in youth. Hypertension 45(4):493–498PubMedGoogle Scholar
  103. Lurbe E, Torro I, Garcia-Vicent C, Alvarez J, Fernandez-Fornoso JA, Redon J (2012) Blood pressure and obesity exert independent influences on pulse wave velocity in youth. Hypertension 60(2):550–555PubMedGoogle Scholar
  104. Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, Wuhl E, Zanchetti A (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens 34(10):1887–1920Google Scholar
  105. Manunta P, Bianchi G (2006) Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives – the adducin paradigm. J Am Soc Nephrol 17(4 Suppl 2):S30–S35PubMedGoogle Scholar
  106. Marcantoni C, Ma LJ, Federspiel C, Fogo AB (2002) Hypertensive nephrosclerosis in African Americans versus Caucasians. Kidney Int 62(1):172–180PubMedGoogle Scholar
  107. Marchesi C, Dentali F, Nicolini E, Maresca AM, Tayebjee MH, Franz M, Guasti L, Venco A, Schiffrin EL, Lip GY, Grandi AM (2012) Plasma levels of matrix metalloproteinases and their inhibitors in hypertension: a systematic review and meta-analysis. J Hypertens 30(1):3–16PubMedGoogle Scholar
  108. Marks SD, Tullus K (2012) Update on imaging for suspected renovascular hypertension in children and adolescents. Curr Hypertens Rep 14(6):591–595PubMedGoogle Scholar
  109. Matteucci MC, Wuhl E, Picca S, Mastrostefano A, Rinelli G, Romano C, Rizzoni G, Mehls O, de Simone G, Schaefer F, ESCAPE Trial Group (2006) Left ventricular geometry in children with mild to moderate chronic renal insufficiency. J Am Soc Nephrol 17(1):218–226PubMedGoogle Scholar
  110. Matthews KA, Woodall KL, Allen MT (1993) Cardiovascular reactivity to stress predicts future blood pressure status. Hypertension 22(4):479–485PubMedGoogle Scholar
  111. Matthews KA, Katholi CR, McCreath H, Whooley MA, Williams DR, Zhu S, Markovitz JH (2004) Blood pressure reactivity to psychological stress predicts hypertension in the CARDIA study. Circulation 110(1):74–78PubMedGoogle Scholar
  112. Mattson DL (2003) Importance of the renal medullary circulation in the control of sodium excretion and blood pressure. Am J Physiol Regul Integr Comp Physiol 284(1):R13–R27PubMedGoogle Scholar
  113. McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150(6):640–644PubMedGoogle Scholar
  114. Mitchell P, Cheung N, de Haseth K, Taylor B, Rochtchina E, Islam FM, Wang JJ, Saw SM, Wong TY (2007) Blood pressure and retinal arteriolar narrowing in children. Hypertension 49(5):1156–1162Google Scholar
  115. Mongeau JG, Biron P, Sing CF (1986) The influence of genetics and household environment upon the variability of normal blood pressure: the Montreal Adoption Survey. Clin Exp Hypertens A 8(4–5):653–660PubMedGoogle Scholar
  116. Muntner P, He J, Cutler JA, Wildman RP, Whelton PK (2004) Trends in blood pressure among children and adolescents. JAMA 291(17):2107–2113PubMedGoogle Scholar
  117. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114(2 Suppl 4th Report):555–576Google Scholar
  118. Neel JV, Weder AB, Julius S (1998) Type II diabetes, essential hypertension, and obesity as “syndromes of impaired genetic homeostasis”: the “thrifty genotype” hypothesis enters the 21st century. Perspect Biol Med 42(1):44–74PubMedGoogle Scholar
  119. Neumann SA, Jennings JR, Muldoon MF, Manuck SB (2005) White-coat hypertension and autonomic nervous system dysregulation. Am J Hypertens 18(5 Pt 1):584–588PubMedGoogle Scholar
  120. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Doring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvanen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dorr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Volker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Volzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB (2009) Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 41(6):666–676PubMedPubMedCentralGoogle Scholar
  121. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY (2008) Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics 121(1):37–45PubMedPubMedCentralGoogle Scholar
  122. Nwankwo T, Yoon SS, Burt V, Gu Q (2013) Hypertension among adults in the United States: National Health and Nutrition Examination Survey, 2011–2012. NCHS Data Brief 133:1–8Google Scholar
  123. Ostchega Y, Carroll M, Prineas RJ, McDowell MA, Louis T, Tilert T (2009) Trends of elevated blood pressure among children and adolescents: data from the National Health and Nutrition Examination Survey 1988–2006. Am J Hypertens 22(1):59–67PubMedGoogle Scholar
  124. Padmanabhan S, Menni C, Lee WK, Laing S, Brambilla P, Sega R, Perego R, Grassi G, Cesana G, Delles C, Mancia G, Dominiczak AF (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. J Hypertens 28(3):465–477PubMedGoogle Scholar
  125. Palar K, Sturm R (2009) Potential societal savings from reduced sodium consumption in the U.S. adult population. Am J Health Promot 24(1):49–57PubMedGoogle Scholar
  126. Pereira TV, Nunes AC, Rudnicki M, Yamada Y, Pereira AC, Krieger JE (2008) Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T? Hypertension 51(3):778–783PubMedGoogle Scholar
  127. Pickering GW (1974) Hypertension: definitions, natural histories and consequences. In: Laragh JH (ed) Hypertension manual: mechanisms, methods, management. Yorke Medical Books, New York, pp 3–10Google Scholar
  128. Pickering TG (1994) Psychosocial stress and hypertension: clinical and experimental evidence. In: Swales JD (ed) Textbook of hypertension. Blackwell Scientific, Oxford, pp 640–654Google Scholar
  129. Pludowski P, Litwin M, Niemirska A, Jaworski M, Sladowska J, Kryskiewicz E, Karczmarewicz E, Neuhoff-Murawska J, Wierzbicka A, Lorenc RS (2009) Accelerated skeletal maturation in children with primary hypertension. Hypertension 54(6):1234–1239PubMedGoogle Scholar
  130. Post RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M (2013) Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder. J Affect Disord 147(1–3):288–294PubMedGoogle Scholar
  131. Ramaswamy P, Chikkabyrappa S, Donda K, Osmolovsky M, Rojas M, Rafii D (2016) Relationship of ambulatory blood pressure and body mass index to left ventricular mass index in pediatric patients with casual hypertension. J Am Soc Hypertens 10(2):108–114PubMedGoogle Scholar
  132. Rao G (2016) Diagnosis, epidemiology, and management of hypertension in children. Pediatrics 138(2)PubMedGoogle Scholar
  133. Redwine KM, Daniels SR (2012) Prehypertension in adolescents: risk and progression. J Clin Hypertens (Greenwich) 14(6):360–364Google Scholar
  134. Redwine KM, Falkner B (2012) Progression of prehypertension to hypertension in adolescents. Curr Hypertens Rep 14(6):619–625PubMedPubMedCentralGoogle Scholar
  135. Redwine KM, Acosta AA, Poffenbarger T, Portman RJ, Samuels J (2012) Development of hypertension in adolescents with pre-hypertension. J Pediatr 160(1):98–103PubMedGoogle Scholar
  136. Rosner B, Cook NR, Daniels S, Falkner B (2013) Childhood blood pressure trends and risk factors for high blood pressure: the NHANES experience 1988–2008. Hypertension 62(2):247–254PubMedPubMedCentralGoogle Scholar
  137. Rudnicki M, Mayer G (2009) Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. Pharmacogenomics 10(3):463–476PubMedGoogle Scholar
  138. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Jarvelin MR, Freimer NB, Peltonen L (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41(1):35–46PubMedGoogle Scholar
  139. Saleh EA, Mahfouz AA, Tayel KY, Naguib MK, Bin-al-Shaikh NM (2000) Hypertension and its determinants among primary-school children in Kuwait: an epidemiological study. East Mediterr Health J 6(2–3):333–337PubMedGoogle Scholar
  140. Samuels JA, Bell C, Flynn JT (2013) Screening children for high blood pressure: where the US Preventive Services Task Force went wrong. J Clin Hypertens (Greenwich) 15(8):526–527Google Scholar
  141. San Jose G, Fortuno A, Beloqui O, Diez J, Zalba G (2008) NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases. Clin Sci (Lond) 114(3):173–182Google Scholar
  142. Schiffrin EL, Touyz RM (2004) From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension. Am J Physiol Heart Circ Physiol 287(2):H435–H446PubMedGoogle Scholar
  143. Sealey JE, Blumenfeld JD, Bell GM, Pecker MS, Sommers SC, Laragh JH (1988) On the renal basis for essential hypertension: nephron heterogeneity with discordant renin secretion and sodium excretion causing a hypertensive vasoconstriction-volume relationship. J Hypertens 6(10):763–777PubMedGoogle Scholar
  144. Seckl JR (1997) Glucocorticoids, feto-placental 11 beta-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease. Steroids 62(1):89–94PubMedGoogle Scholar
  145. Seeman T, Pohl M, Palyzova D, John U (2012) Microalbuminuria in children with primary and white-coat hypertension. Pediatr Nephrol 27(3):461–467Google Scholar
  146. Sethi AA, Nordestgaard BG, Tybjaerg-Hansen A (2003) Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol 23(7):1269–1275PubMedGoogle Scholar
  147. Sharma A, Grover N, Kaushik S, Bhardwaj R, Sankhyan N (2010) Prevalence of hypertension among schoolchildren in Shimla. Indian Pediatr 47(10):873–876PubMedGoogle Scholar
  148. Shear CL, Burke GL, Freedman DS, Berenson GS (1986) Value of childhood blood pressure measurements and family history in predicting future blood pressure status: results from 8 years of follow-up in the Bogalusa Heart Study. Pediatrics 77(6):862–869PubMedGoogle Scholar
  149. Sheppard R (2010) Vascular tone and the genomics of hypertension. Heart Fail Clin 6(1):45–53PubMedGoogle Scholar
  150. Siegel JM, Matthews KA, Leitch CJ (1983) Blood pressure variability and the type A behavior pattern in adolescence. J Psychosom Res 27(4):265–272PubMedGoogle Scholar
  151. Simoes ESAC, Flynn JT (2012) The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease. Pediatr Nephrol 27(10):1835–1845Google Scholar
  152. Simonetti GD, VON Vigier RO, Wuhl E, Mohaupt MG (2008) Ambulatory arterial stiffness index is increased in hypertensive childhood disease. Pediatr Res 64(3):303–307PubMedGoogle Scholar
  153. Simonetti GD, Schwertz R, Klett M, Hoffmann GF, Schaefer F, Wuhl E (2011) Determinants of blood pressure in preschool children: the role of parental smoking. Circulation 123(3):292–298PubMedGoogle Scholar
  154. Sober S, Org E, Kepp K, Juhanson P, Eyheramendy S, Gieger C, Lichtner P, Klopp N, Veldre G, Viigimaa M, Doring A, Kooperative Gesundheitsforschung in der Region Augsburg S, Putku M, Kelgo P, Study HYE, Shaw-Hawkins S, Howard P, Onipinla A, Dobson RJ, Newhouse SJ, Brown M, Dominiczak A, Connell J, Samani N, Farrall M, Study MRCBGoH, Caulfield MJ, Munroe PB, Illig T, Wichmann HE, Meitinger T, Laan M (2009) Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS One 4(6):e6034PubMedPubMedCentralGoogle Scholar
  155. Sorof JM, Portman RJ (2000) Ambulatory blood pressure monitoring in the pediatric patient. J Pediatr 136(5):578–586PubMedGoogle Scholar
  156. Sorof JM, Poffenbarger T, Franco K, Portman R (2001) Evaluation of white coat hypertension in children: importance of the definitions of normal ambulatory blood pressure and the severity of casual hypertension. Am J Hypertens 14(9 Pt 1):855–860PubMedGoogle Scholar
  157. Sorof JM, Poffenbarger T, Franco K, Bernard L, Portman RJ (2002) Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children. J Pediatr 140(6):660–666Google Scholar
  158. Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ (2004) Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics 113(3 Pt 1):475–482Google Scholar
  159. Stabouli S, Kotsis V, Rizos Z, Toumanidis S, Karagianni C, Constantopoulos A, Zakopoulos N (2009) Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents. Pediatr Nephrol 24(8):1545–1551PubMedGoogle Scholar
  160. Stein DJ, Scott K, Haro Abad JM, Aguilar-Gaxiola S, Alonso J, Angermeyer M, Demytteneare K, de Girolamo G, Iwata N, Posada-Villa J, Kovess V, Lara C, Ormel J, Kessler RC, Von Korff M (2010) Early childhood adversity and later hypertension: data from the World Mental Health Survey. Ann Clin Psychiatry 22(1):19–28PubMedPubMedCentralGoogle Scholar
  161. Steinberger J, Daniels SR, Hagberg N, Isasi CR, Kelly AS, Lloyd-Jones D, Pate RR, Pratt C, Shay CM, Towbin JA, Urbina E, Van Horn LV, Zachariah JP, American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Functional Genomics and Translational Biology, Stroke Council (2016) Cardiovascular health promotion in children: challenges and opportunities for 2020 and beyond: a scientific statement from the American Heart Association. CirculationGoogle Scholar
  162. Steinthorsdottir SD, Eliasdottir SB, Indridason OS, Agustsdottir IM, Palsson R, Edvardsson VO (2011) Prevalence of hypertension in 9- to 10-year-old Icelandic school children. J Clin Hypertens (Greenwich) 13(10):774–779Google Scholar
  163. Stewart JC, France CR (2001) Cardiovascular recovery from stress predicts longitudinal changes in blood pressure. Biol Psychol 58(2):105–120PubMedGoogle Scholar
  164. Sulakova T, Janda J, Cerna J, Janstova V, Sulakova A, Slany J, Feber J (2009) Arterial HTN in children with T1DM – frequent and not easy to diagnose. Pediatr Diabetes 10(7):441–448PubMedGoogle Scholar
  165. Sun SS, Grave GD, Siervogel RM, Pickoff AA, Arslanian SS, Daniels SR (2007) Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life. Pediatrics 119(2):237–246PubMedGoogle Scholar
  166. Thompson M, Dana T, Bougatsos C, Blazina I, Norris SL (2013) Screening for hypertension in children and adolescents to prevent cardiovascular disease. Pediatrics 131(3):490–525PubMedGoogle Scholar
  167. Timofeeva AV, Goryunova LE, Khaspekov GL, Kovalevskii DA, Scamrov AV, Bulkina OS, Karpov YA, Talitskii KA, Buza VV, Britareva VV, Beabealashvilli R (2006) Altered gene expression pattern in peripheral blood leukocytes from patients with arterial hypertension. Ann N Y Acad Sci 1091:319–335PubMedGoogle Scholar
  168. Tomaszewski M, Debiec R, Braund PS, Nelson CP, Hardwick R, Christofidou P, Denniff M, Codd V, Rafelt S, van der Harst P, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Burton PR, Mooser V, Charchar FJ, Thompson JR, Tobin MD, Samani NJ (2010) Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension 56(6):1069–1076PubMedPubMedCentralGoogle Scholar
  169. Toschke AM, Kohl L, Mansmann U, von Kries R (2010) Meta-analysis of blood pressure tracking from childhood to adulthood and implications for the design of intervention trials. Acta Paediatr 99(1):24–29PubMedGoogle Scholar
  170. Treiber FA, Turner JR, Davis H, Strong WB (1997) Prediction of resting cardiovascular functioning in youth with family histories of essential hypertension: a 5-year follow-up. Int J Behav Med 4(4):278–291PubMedGoogle Scholar
  171. Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD, Roebuck DJ (2008) Renovascular hypertension in children. Lancet 371(9622):1453–1463PubMedGoogle Scholar
  172. Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, Mahoney L, McCrindle B, Mietus-Snyder M, Steinberger J, Daniels S, American Heart Association Atherosclerosis Hypertension, Obesity in Youth Committee (2008) Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. Hypertension 52(3):433–451PubMedGoogle Scholar
  173. Urbina EM, Kimball TR, McCoy CE, Khoury PR, Daniels SR, Dolan LM (2009) Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation 119(22):2913–2919PubMedPubMedCentralGoogle Scholar
  174. Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM (2011) Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens (Greenwich) 13(5):332–342Google Scholar
  175. Vaindirlis I, Peppa-Patrikiou M, Dracopoulou M, Manoli I, Voutetakis A, Dacou-Voutetakis C (2000) “White coat hypertension” in adolescents: increased values of urinary cortisol and endothelin. J Pediatr 136(3):359–364PubMedGoogle Scholar
  176. Verberk WJ, Kessels AG, de Leeuw PW (2008) Prevalence, causes, and consequences of masked hypertension: a meta-analysis. Am J Hypertens 21(9):969–975PubMedGoogle Scholar
  177. Watson B Jr, Khan MA, Desmond RA, Bergman S (2001) Mitochondrial DNA mutations in black Americans with hypertension-associated end-stage renal disease. Am J Kidney Dis 38(3):529–536PubMedGoogle Scholar
  178. Weder AB, Schork NJ (1994) Adaptation, allometry, and hypertension. Hypertension 24(2):145–156PubMedGoogle Scholar
  179. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661–678Google Scholar
  180. Whincup PH, Gilg JA, Donald AE, Katterhorn M, Oliver C, Cook DG, Deanfield JE (2005) Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation 112(12):1789–1797PubMedGoogle Scholar
  181. Wilson SL, Gaffney FA, Laird WP, Fixler DE (1985) Body size, composition, and fitness in adolescents with elevated blood pressures. Hypertension 7(3 Pt 1):417–422PubMedGoogle Scholar
  182. Wong LJ, Kupferman JC, Prohovnik I, Kirkham FJ, Goodman S, Paterno K, Sharma M, Brosgol Y, Pavlakis SG (2011) Hypertension impairs vascular reactivity in the pediatric brain. Stroke 42(7):1834–1838Google Scholar
  183. World Health Organization (2013) A global brief on hypertension 2013, document number: WHO/DCO/WHD/2013.2. WHO Press, GenevaGoogle Scholar
  184. Wu X, Kan D, Province M, Quertermous T, Rao DC, Chang C, Mosley TH, Curb D, Boerwinkle E, Cooper RS (2006) An updated meta-analysis of genome scans for hypertension and blood pressure in the NHLBI Family Blood Pressure Program (FBPP). Am J Hypertens 19(1):122–127PubMedGoogle Scholar
  185. Yamaguchi I, Flynn JT (2009) Pathophysiology of hypertension. In: Avner E, Harmon W, Niaudet P, Yoshikawa N (eds) Pediatric Nephrologu, 6th edn. Lippincott Williams and Wilkins, Philadelphia, pp 1485–1518Google Scholar
  186. Zhu H, Wang X, Lu Y, Poola J, Momin Z, Harshfield GA, Snieder H, Dong Y (2006) Update on G-protein polymorphisms in hypertension. Curr Hypertens Rep 8(1):23–29PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Wayne State University School of Medicine, Children’s Hospital of MichiganDetroitUSA

Section editors and affiliations

  • Joseph T. Flynn
    • 1
    • 2
  1. 1.Division of NephrologySeattle Children’s HospitalSeattleUSA
  2. 2.Department of PediatricsUniversity of Washington School of MedicineSeattleUSA

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