Inflammation and Perinatal Brain Injury
Inflammation is a critical contributor to both normal development and injury outcome in the immature brain. The consequences of immune activation in brain injury will be entirely different depending on context and stage of central nervous system (CNS) maturity. The immature brain can be exposed to inflammation in connection with viral or bacterial infection during pregnancy or as a result of sterile CNS insults such as hypoxia-ischemia and neonatal stroke. Through efficient anti-inflammatory and reparative processes, inflammation may resolve without any harmful effects on the brain. Alternatively, inflammation contributes to injury or enhances CNS vulnerability. Acute inflammation can also be shifted to a chronic inflammatory state and/or adversely affect brain development resulting in neurologic disease in children or adults.
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