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Neonatology pp 2019-2030 | Cite as

Inflammation and Perinatal Brain Injury

  • Henrik Hagberg
  • Carina Mallard
  • Karin Sävman
Reference work entry

Abstract

Inflammation is a critical contributor to both normal development and injury outcome in the immature brain. The consequences of immune activation in brain injury will be entirely different depending on context and stage of central nervous system (CNS) maturity. The immature brain can be exposed to inflammation in connection with viral or bacterial infection during pregnancy or as a result of sterile CNS insults such as hypoxia-ischemia and neonatal stroke. Through efficient anti-inflammatory and reparative processes, inflammation may resolve without any harmful effects on the brain. Alternatively, inflammation contributes to injury or enhances CNS vulnerability. Acute inflammation can also be shifted to a chronic inflammatory state and/or adversely affect brain development resulting in neurologic disease in children or adults.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Henrik Hagberg
    • 1
    • 2
  • Carina Mallard
    • 3
  • Karin Sävman
    • 4
  1. 1.Perinatal Center, Department of Obstetrics and GynecologySahlgrenska Academy, University of GothenburgGoteborgSweden
  2. 2.Centre for the Developing Brain, Division of Imaging Sciences and Biomedical EngineeringKing’s College London, King’s Health Partners, St. Thomas’ HospitalLondonUK
  3. 3.Department of Physiology, Institute of Neuroscience and PhysiologySahlgrenska Academy, University of GothenburgGothenburgSweden
  4. 4.Department of PediatricsSahlgrenska Academy, University of GothenburgGothenburgSweden

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