Neonatology pp 1773-1784 | Cite as

Neonatal Septic Shock

  • Rajesh K. AnejaEmail author
  • Ruby V. Aneja
  • Misty Good
  • Joseph A. Carcillo
Reference work entry


Neonatal sepsis continues to be a major health problem in the world. Over the last decade, there has been an overall decrease in the incidence of neonatal sepsis. The institution of intrapartum Group B Streptococcus (GBS) prophylaxis has also led to a decrease in GBS early-onset disease. Early recognition and treatment of sepsis is essential to halt its progression to severe sepsis and septic shock. In this chapter, we compare the essential differences between the hemodynamic response to shock in neonates and older children. We also discuss various factors that make diagnosis and treatment of neonatal shock challenging. The American College of Critical Care Medicine recently published an update to their clinical practice parameters for the management of septic shock. We summarize these guidelines and briefly review thrombocytopenia-associated multiple organ failure in sepsis.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rajesh K. Aneja
    • 1
    Email author
  • Ruby V. Aneja
    • 2
  • Misty Good
    • 3
  • Joseph A. Carcillo
    • 1
  1. 1.Departments of Critical Care Medicine and PediatricsUniversity of Pittsburgh School of Medicine, Children’s Hospital of PittsburghPittsburghUSA
  2. 2.Division of NeonatologyTemple University, West Penn HospitalPittsburghUSA
  3. 3.Division of NeonatologyUniversity of Pittsburgh School of Medicine, Children’s Hospital of PittsburghPittsburghUSA

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