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Neonatology pp 1703-1710 | Cite as

Fetal Infections: Congenital Syphilis and Tuberculosis

  • Pier Angelo Tovo
  • Carlo Scolfaro
  • Silvia Garazzino
  • Federica Mignone
Reference work entry

Abstract

Syphilis is a major public health problem in developing countries, and it is also resurging in the industrialized world. Congenital tuberculosis (TB) is rare, but it may be fatal if untreated. Infection of the fetus may be the consequence of hematogenous spread, aspiration or ingestion of contaminated amniotic fluid, or contact with maternal genital lesions at delivery. In infants signs and symptoms may be nonspecific, mimicking other disseminated infections. Early recognition is essential for a prompt treatment, as the mortality rate of untreated forms is approximately 50%. Initial therapy consists in the combination of four first-line antituberculous drugs, although the optimal regimen and duration of treatment remain to be established.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Pier Angelo Tovo
    • 1
  • Carlo Scolfaro
    • 1
  • Silvia Garazzino
    • 1
  • Federica Mignone
    • 1
  1. 1.Department of PediatricsUniversity of Turin, Regina Margherita Childrens Hospital, AOU Città della Salute e della Scienza di TorinoTurinItaly

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