Neonatology pp 1561-1573 | Cite as

Recombinant G-CSF Treatment of Severe Chronic Neutropenia in Neonates and Infants

  • Robert D. ChristensenEmail author
Reference work entry


Neutropenia is a condition characterized by a diminution in the number of circulating neutrophils and increases susceptibility to local and systemic infections. Neutropenia can be a transient and benign condition, in which there is no need of specific therapy, except for intercurrent situations, such as antibiotic therapy in infections. Alternatively, it can be part of a more complex and severe situation, associated with other organ dysfunctions or malformations. Severe chronic neutropenia is a group of diagnoses characterized by hyporegenerative neutropenia, generally present from birth; these newborns and children often need the administration of recombinant granulocyte colony-stimulating factor (rG-CSF). The advent of rG-CSF dramatically improved the lives of these patients, elevating their circulating neutrophil concentrations, markedly reducing infectious illnesses, and extending life expectancy. When a transient variety of neonatal neutropenia is diagnosed, distinct from severe chronic neutropenia (SCN), the benefit of rG-CSF treatment is unproven and of dubious value.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Divisions of Neonatology and Hematology, Department of PediatricsUniversity of Utah School of Medicine, Intermountain HealthcareSalt Lake CityUSA

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