Neonatology pp 1431-1453 | Cite as

Pathophysiology of Coagulation and Deficiencies of Coagulation Factors in Newborn

  • Paola SaraccoEmail author
  • Rodney P. A. Rivers
Reference work entry


The hemostatic system of the neonate is dynamically evolving and different from older children and very different from the adult. The main points of difference between neonatal and adult hemostasis are as follows:
  • Platelets show significant differences in function.

  • Bleeding times are shorter through increased activity of von Willebrand factor (VWF).

  • Many procoagulant and inhibitor levels are gestationally dependent.

  • Reduced procoagulant and inhibitor reserve.

  • Relatively impaired fibrinolysis.

  • This neonatal coagulopathy impacts both the diagnosis and management of hemorrhagic or thrombotic events in neonates. Diagnostic laboratories should use age-analyzer and reagent-appropriate references ranges.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pediatric Hematology, Department of PediatricsUniversity Hospital Città della Salute e della ScienzaTorinoItaly
  2. 2.Section of Paediatrics, Department of MedicineImperial CollegeLondonUK

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