Neonatology pp 1405-1430 | Cite as

Hematology and Immunology of Newborns: Overview

  • Robert D. ChristensenEmail author
Reference work entry


Normal ranges for hematologic values in adult medicine are established by drawing blood from large numbers of healthy adult volunteers. These are not available for newborns; therefore, neonatal hematology utilizes the concept of “reference intervals” which consist of 5th to 95th percentile values compiled from laboratory tests performed on selected neonates from whom a complete blood count (CBC) was drawn for a clinical purpose. The various blood cell counts of neonates must be interpreted in accordance with reference intervals based on gestational and postnatal age. Making a judgment about whether a hematological value is normal or abnormal requires cognizance of other factors such as any specific illnesses involved, the level of intensive care support given, and the anatomical site of the blood sampling (venous, arterial, capillary). Reference intervals for hemoglobin, hematocrit, erythrocyte indices, reticulocyte count, neutrophil and eosinophil concentrations, platelet count, and mean platelet volume are reported in this chapter. Reference values are not available for bone marrow aspirate or biopsy, since they are usually performed on not strictly normal subjects.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Divisions of Neonatology and Hematology, Department of PediatricsUniversity of Utah School of Medicine, Intermountain HealthcareSalt Lake CityUSA

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