Neonatology pp 1151-1167 | Cite as

Pathologic Unconjugated Hyperbilirubinemia–Isoimmunization, Abnormalities of Red Blood Cells, and Infections

  • Michael KaplanEmail author
  • Ronald J. Wong
  • David K. Stevenson
Reference work entry


Although pathologic unconjugated hyperbilirubinemia can be best understood in terms of primary problems with bilirubin uptake and conjugation, most pathologic unconjugated hyperbilirubinemia occurring after birth and requiring treatment is often associated with increased bilirubin production and further exacerbated by environmental or acquired factors, such as isoimmunization, abnormalities of red blood cells, and infection. This chapter will describe the etiology and pathogenesis of unconjugated hyperbilirubinemia, its genetic predisposition, as well as current screening tools and treatment strategies.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Michael Kaplan
    • 1
    • 2
    Email author
  • Ronald J. Wong
    • 3
  • David K. Stevenson
    • 4
  1. 1.Department of NeonatologyShaare Zedek Medical CenterJerusalemIsrael
  2. 2.The Faculty of MedicineHebrew UniversityJerusalemIsrael
  3. 3.Department of PediatricsStanford University School of MedicineStanfordUSA
  4. 4.Department of PediatricsStanford University School of Medicine, Medical School Office BuildingStanfordUSA

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