Neonatology pp 1079-1091 | Cite as

Patent Ductus Arteriosus

  • Bart Van Overmeire
Reference work entry


Patent ductus arteriosus (PDA) continues to be a frequent complication of extremely premature birth, despite the more generalized use of antenatal steroids, postnatal surfactant administration, and the improvement of noninvasive ventilatory strategies. Its incidence is inversely related to gestational age, such that it affects almost 60% of infants less than 28 weeks’ gestation. Spontaneous closure of the ductus occurs in 30% of infants with very low birth weight (<1500 g). When the PDA is hampering the neonate’s well-being, judicious evaluation and tailoring of the best therapeutic strategy should be performed. Ibuprofen actually seems to be the preferred drug for pharmacological treatment because of its favorable risk/benefit ratio; the therapeutic response of the most immature infants however is limited. Surgical ligation of the duct should be considered as a backup treatment due to the risks of serious complications during and after the procedure.


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Authors and Affiliations

  • Bart Van Overmeire
    • 1
  1. 1.Neonatology ServiceErasmus Hospital Université Libre de BruxellesBrusselsBelgium

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