Neonatology pp 801-807 | Cite as

Molecular Structure of Surfactant: Biochemical Aspects in Newborns

  • Tore CurstedtEmail author
Reference work entry


The surfactant-lining alveolar surface is a prerequisite for gas exchange in order to fulfill the energy needs of the living organism. Surfactant is composed of lipids, mainly phospholipids, and four surfactant-associated proteins. It facilitates alveolar increase during inspiration and prevents their collapse at end-expiration. Insufficient amounts of surfactant in premature babies can be successfully treated with surfactant preparations derived from animal lungs. Preliminary studies show that in a near future synthetic surfactants may replace or be an alternative to animal-derived preparations.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Molecular Medicine and SurgeryKarolinska Institutet, Karolinska University HospitalStockholmSweden

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