Pseudosarcomatous Myofibroblastic Proliferations
A benign lesion of myofibroblasts showing overlap with nodular fasciitis, inflammatory myofibroblastic tumor, and granulation tissue.
Mainly seen in adults.
No gender predilection.
The mucosal surface of the genitourinary tract is mostly affected, but the lesions can occur at any mucosal site of the gastrointestinal tract and head and neck area (Proppe et al. 1984; Harik et al. 2006).
Surgical excision usually is curative.
These lesions are benign but can occasionally recur.
The lesion usually presents as polypoid, exophytic, and ulcerated masses.
- Jebastin, J. A. S., Smith, S. C., Perry, K. D., Gupta, N. S., Alanee, S., Carskadon, S., Chitale, D. A., Palanisamy, N., & Williamson, S. R. (2018). Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements. Histopathology, 73, 321–326.CrossRefGoogle Scholar
- Marino-Enriquez, A., & Hornick, J. L. (2019). Pseudosarcomatous myofibroblastic proliferation. In J. L. Hornick (Ed.), Practical soft tissue pathology (pp. 25–27). Philadelphia: Elsevier.Google Scholar