Pleomorphic Fibroma

Definition

Pleomorphic fibromas are benign polypoid stromal proliferations containing bizarre appearing and often multinucleated cells.

Clinical Features

• Incidence

  Rare but no accurate data exist on incidence.

• Age

  There is a predilection for middle-aged adults (Kamino et al. 1989).

• Sex

  Females are slightly more frequently affected than males.

• Site

  The extremities are most commonly affected followed by the trunk (Kamino et al. 1989).

• Treatment

  No specific treatment is necessary and simple excision is curative.

• Outcome

  Pleomorphic fibromas are benign.

Macroscopy

Pleomorphic fibroma presents as solitary, flesh-colored, dome-shaped papules or polypoid nodules measuring few millimeters up to 1.5 centimeters (Kamino et al. 1989).

Microscopy

Pleomorphic fibromas are nodular or polypoid dermal-based tumors containing scattered large, spindled to stellate cells in a collagenous stroma (Fig. 1). The tumor cells contain pleomorphic and hyperchromatic nuclei. Multinucleated forms are common (Fig. 2...