Low-Grade Myofibroblastic Sarcoma
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Low-grade myofibroblastic sarcoma (LGMFS) is a malignant tumor showing myofibroblastic differentiation. Myofibroblasts are modified fibroblasts that acquire contractile cytoplasmic actin-containing microfilaments (stress fibers) and a specific cell-to-stroma attachment complex, the fibronexus or microtendon. Other ultrastructural features of myofibroblasts are a well-developed rough endoplasmic reticulum, Golgi complex, and collagen secretion granules in Golgi-derived vesicles. Myofibroblasts are the major constituent of granulation tissue, but they are also found in benign soft tissue lesions, like nodular fasciitis, as well as in low-grade and high-grade sarcomas as a minor component.