Disseminated Peritoneal Leiomyomatosis (Leiomyomatosis Peritonealis Disseminata)
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A disorder characterized by multiple, often numerous, banal-appearing smooth muscle neoplasms involving the peritoneal and abdominal cavity.
Disseminated peritoneal leiomyomatosis is uncommon and often discovered incidentally. Most (>70%) occur in women who are currently or recently pregnant or who are on oral contraception. Rarely, it occurs in the setting of an estrogen-producing ovarian tumor. This condition may also occur following unconfined morcellation of otherwise benign uterine leiomyomata.
Patients are typically reproductive aged, but occasionally this disorder can occur in postmenopausal women.
This condition occurs in women.
Tumors typically involve surfaces of the peritoneal and abdominal cavity.
Persistent and unresectable disease has been successfully treated with gonadotropin-releasing hormone agonists or aromatase inhibitors.
Patients typically have a benign clinical course and aggressive...
References and Further Reading
- Büttner, A., Bässler, R., & Theele, C. (1993). Pregnancy-associated ectopic decidua (deciduosis) of the greater omentum. An analysis of 60 biopsies with cases of fibrosing deciduosis and leiomyomatosis peritonealis disseminata. Pathology, Research and Practice, 189(3), 352–359.CrossRefGoogle Scholar
- Drake, A., Dhundee, J., Buckley, C. H., et al. (2001). Disseminated leiomyomatosis peritonealis in association with oestrogen secreting ovarian fibrothecoma. BJOG: An International Journal of Obstetrics and Gynaecology, 108(6), 661–664.Google Scholar
- Ordulu, Z., Dal Cin, P., Chong, W. W., Choy, K. W., Lee, C., Muto, M. G., Quade, B. Q., & Morton, C. C. (2010). Disseminated peritoneal leiomyomatosis after laparoscopic supracervical hysterectomy with characteristic molecular cytogenetic findings of uterine leiomyoma. Genes, Chromosomes & Cancer, 49(12), 1152–1160.CrossRefGoogle Scholar
- Quade, B. J., McLachlin, C. M., Soto-Wright, V., Zuckerman, J., Mutter, G. L., & Morton, C. C. (1997). Disseminated peritoneal leiomyomatosis. Clonality analysis by X chromosome inactivation and cytogenetics of the clinically benign smooth muscle proliferation. The American Journal of Pathology, 150(60), 2153–2166.PubMedPubMedCentralGoogle Scholar
- Rieker, R. J., Agaimy, A., Moskalev, E. A., et al. (2013). Mutation status of the mediator complex subunit 12 (MED12) in uterine leiomyomas and concurrent/metachronous multifocal peritoneal smooth muscle nodules (leiomyomatosis peritonealis disseminata). Pathology, 45(4), 388–392.CrossRefGoogle Scholar