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Encyclopedia of Pathology pp 1–3Cite as

Hemosiderotic Fibrolipomatous Tumor

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Hemosiderotic fibrolipomatous lesion

Definition

Is a locally aggressive fibrolipomatous, hemosiderin-rich neoplasia

Clinical Features

  • Incidence

    Rare soft tissue neoplasm

  • Age

    Occur mainly in the fifth and sixth decade of life (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).

  • Sex

    Affects predominantly women (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).

  • Site

    Most commonly affected sites are the dorsum of the foot and the ankle region. Less frequently effected regions include the upper limbs, hands, and the head/neck region (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).

  • Treatment

    Complete surgical excision is the treatment of choice.

  • Outcome

    The local recurrence rate is 30–50% if initially incompletely excised. Complete excision is generally curative (Marshall-Taylor and Fanburg-Smith 2000; Browne and Fletcher 2006).

Macroscopy

HFLT is an ill-defined yellowish-brown tumor with a tumor size ranging from 1 to 20 cm...

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References and Further Reading

  • Antonescu, C. R., Zhang, L., Nielsen, G. P., et al. (2011). Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. Genes, Chromosomes and Cancer, 50, 757–764. PMID: 21717526.

    Article  CAS  Google Scholar 

  • Browne, T. J., & Fletcher, C. D. (2006). Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): Analysis of 13 new cases in support of a distinct entity. Histopathology, 48, 453–461. PMID: 16487368.

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  • Elco, C. P., Mariño-Enríquez, A., Abraham, J. A., et al. (2010). Hybrid myxoinflammatory fibroblastic sarcoma/hemosiderotic fibrolipomatous tumor: Report of a case providing further evidence for a pathogenetic link. The American Journal of Surgical Pathology, 34, 1723–1727. PMID: 20871391.

    PubMed  Google Scholar 

  • Hallor, K. H., Sciot, R., Staaf, J., et al. (2009). Two genetic pathways, t(1;10) and amplification of 3p11–12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions. The Journal of Pathology, 217, 716–727. PMID: 19199331.

    Article  CAS  Google Scholar 

  • Marshall-Taylor, C., & Fanburg-Smith, J. C. (2000). Hemosiderotic fibrohistiocytic lipomatous lesion: Ten cases of a previously undescribed fatty lesion of the foot/ankle. Modern Pathology, 13, 1192–1199. PMID: 11106076.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria

    Bernadette Liegl-Atzwanger

Authors
  1. Bernadette Liegl-Atzwanger
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Corresponding author

Correspondence to Bernadette Liegl-Atzwanger .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Liegl-Atzwanger, B. (2020). Hemosiderotic Fibrolipomatous Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5397-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5397-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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