Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Chondroma of Soft Parts

  • Yin P. Hung
  • G. Petur NielsenEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_5366-1



Chondroma of soft tissue is a benign tumor composed of hyaline cartilage that is located in the soft tissue, with no association with bone, synovium, or tendon sheath.

Clinical Features

  • Incidence

    Chondroma of soft tissue is uncommon and comprises <1% of all cartilaginous tumors.

  • Age

    Chondroma of soft tissue affects adults with a wide age range, most commonly in the third to fourth decade of life (Chung and Enzinger 1978; Dahlin and Salvador 1974).

  • Sex

    Slight predominance for males (M:F = 1.5) has been noted in a large series of 104 chondromas of soft tissue (Chung and Enzinger 1978).

  • Site

    Chondroma of soft tissue involves most commonly the distal extremity (digit, hand, or foot), rarely the trunk or the head and neck region. Other exceptional sites of involvement reported include the liver, testis, bladder, and fallopian tube.

    Radiographically, on plain films, computed tomography (CT), or...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Amary, F., Perez-Casanova, L., Ye, H., Cottone, L., Strobl, A. C., Cool, P., … & Flanagan, A. M. (2019). Synovial chondromatosis and soft tissue chondroma: Extraosseous cartilaginous tumor defined by FN1 gene rearrangement. Modern Pathology.  https://doi.org/10.1038/s41379-019-0315-8.
  2. Cates, J. M., Rosenberg, A. E., O’Connell, J. X., & Nielsen, G. P. (2001). Chondroblastoma-like chondroma of soft tissue: An underrecognized variant and its differential diagnosis. The American Journal of Surgical Pathology, 25(5), 661–666.CrossRefGoogle Scholar
  3. Chung, E. B., & Enzinger, F. M. (1978). Chondroma of soft parts. Cancer, 41(4), 1414–1424.  https://doi.org/10.1002/1097-0142(197804)41:4<1414::aid-cncr2820410429>3.0.co;2-o.CrossRefPubMedGoogle Scholar
  4. Dahlen, A., Mertens, F., Rydholm, A., Brosjo, O., Wejde, J., Mandahl, N., & Panagopoulos, I. (2003). Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. Modern Pathology, 16(11), 1132–1140.  https://doi.org/10.1097/01.MP.0000092954.42656.94.CrossRefPubMedGoogle Scholar
  5. Dahlin, D. C., & Salvador, A. H. (1974). Cartilaginous tumors of the soft tissues of the hands and feet. Mayo Clinic Proceedings, 49(10), 721–726.PubMedGoogle Scholar
  6. Fetsch, J. F., Vinh, T. N., Remotti, F., Walker, E. A., Murphey, M. D., & Sweet, D. E. (2003). Tenosynovial (extraarticular) chondromatosis: An analysis of 37 cases of an underrecognized clinicopathologic entity with a strong predilection for the hands and feet and a high local recurrence rate. The American Journal of Surgical Pathology, 27(9), 1260–1268.CrossRefGoogle Scholar
  7. Shon, W., & Folpe, A. L. (2013). Myxochondroid metaplasia of the plantar foot: A distinctive pseudoneoplastic lesion resembling nuchal fibrocartilaginous pseudotumor and the equine digital cushion. Modern Pathology, 26(12), 1561–1567.  https://doi.org/10.1038/modpathol.2013.116.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA