A benign, well-circumscribed tumor of the pelvicoperineal region composed of a prominent vascular and stromal component, the latter showing myofibroblastic differentiation
Angiomyofibroblastoma is uncommon.
These tumors typically occur in adults over a wide age range. In women, approximately 10% occur following menopause.
Angiomyofibroblastoma more commonly occurs in women.
These tumors arise in the subcutaneous tissue of the pelvicoperineum, with the vulva being the most common location. Clinically, they are often thought to represent a Bartholin gland cyst. Approximately 10–15% occur in the vagina. In men, they occur in paratesticular soft tissue or the scrotum.
Local excision is adequate treatment.
Angiomyofibroblastoma is benign. Recurrence is rare even after marginal excision.
These tumors usually measure <5 cm and are well demarcated but lack a capsule. They typically have a soft to rubbery...
References and Further Reading
- Chen, B. J., Marino-Enriquez, A., Fletcher, C. D., & Hornick, J. L. (2012). Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: An immunohistochemical study with diagnostic implications. The American Journal of Surgical Pathology, 36, 1119–1128.CrossRefGoogle Scholar
- Luis, P. P., Quiñonez, E., Nogales, F. F., et al. (2015). Lipomatous variant of angiomyofibroblastoma involving the vulva: Report of 3 cases of an extremely rare neoplasm with discussion of the differential diagnosis. International Journal of Gynecological Pathology, 34(2), 204–207.CrossRefGoogle Scholar