Granular Cell Tumor, Genitourinary Tract

Synonyms

Granular cells myoblastoma (obsolete)

Definition

Granular cell tumor (GCT) is a benign neuroectodermal tumor composed by large polygonal cells with abundant granular cytoplasm (Gurzu et al. 2015). The lesion is usually benign, even though rare malignant cases are reported (Richmond et al. 2016; Fanburg-Smith et al. 1998).

Clinical Features

• Incidence

  Granular cell tumor is quite rare in the male genitourinary tract. Indeed, 17 cases are reported in the bladder and < 20 cases in male genitalia (Bedir et al. 2017; Pu et al. 2015).

• Age

  The lesion can occur at all ages (bladder 14–70 years, external male genitalia 6–89) (Cheville and Folpe 2016; Richmond et al. 2016; Pu et al. 2015).

• Sex

  In the bladder, it occurs in both males and females, while in the external genitalia occurs only in males (Cheville and Folpe 2016; Bedir et al. 2017; Pu et al. 2015; Richmond et al. 2016).

• Site

  The tumor can occur in the bladder, urethra, external genital tract (penis and scrotum), and...