Definition
Clear cell glycogen-rich urothelial carcinoma is defined as a variant of urothelial carcinoma with cells with glycogen-rich cytoplasm. The clarity of the cells may simulate clear cell renal cell carcinoma or clear cell carcinomas for other organs (Lopez-Beltran et al. 2019).
Clinical Features
Incidence
Foci of clear cells are present in about 30% of high-grade urothelial carcinoma. The pure glycogen-rich urothelial carcinoma represents an unusual variant with few cases reported so far (Kramer et al. 2012; Knez et al. 2014; Zhang et al. 2014; Moradi et al. 2017).
Age
It occurs in adult age.
Sex
It presents a male predominance.
Site
It occurs mainly in the bladder, and it however may involve the urinary tract organs in pure form or more common with urothelial carcinoma conventional type (Perez-Montiel et al. 2006).
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References and Further Reading
Knez, V. M., Barrow, W., Lucia, M. S., et al. (2014). Clear cell urothelial carcinoma of the urinary bladder: A case report and review of the literature. Journal of Medical Case Reports, 8, 275.
Kramer, M. W., Abbas, M., Pertschy, S., et al. (2012). Clear-cell variant urothelial carcinoma of the bladder: A case report and review of the literature. Rare Tumors, 4, 153–155.
Lopez-Beltran, A., Henriques, V., Montironi, R., et al. (2019). Variants and new entities of bladder cancer. Histopathology, 74, 77–96.
Moradi, M., Shojaei, S., Kaseb, K., & Rezaee, H. (2017). Primary clear cell carcinoma of urinary bladder: A case report. Urology Case Reports, 16, 41–43.
Oliva, E., Amin, M. B., Jimenez, R., et al. (2002). Clear cell carcinoma of the urinary bladder: A report and comparison of four tumors of Müllerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. The American Journal of Surgical Pathology, 26, 190–197.
Paner, G. P., Annaiah, C., Gulmann, C., et al. (2014). Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder. Human Pathology, 45, 1473–1482.
Perez-Montiel, D., Wakely, P. E., Hes, O., et al. (2006). High-grade urothelial carcinoma of the renal pelvis: Clinicopathologic study of 108 cases with emphasis on unusual morphologic variants. Modern Pathology, 19, 494–503.
Zhang, Y., Huang, J., Feng, H., & Tang, Y. (2014). Primary multiple clear cell variant urothelial carcinomas of urinary bladder: A rare case report. International Journal of Clinical and Experimental Pathology, 7, 3385–3388.
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Canas-Marques, R., Raspollini, M.R., Cimadamore, A., Montironi, R., Lopez-Beltran, A. (2020). Urothelial Carcinoma, Clear Cell (Glycogen-Rich) Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4982-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4982-1
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