Urothelial Carcinoma, Clear Cell (Glycogen-Rich) Type
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Clear cell glycogen-rich urothelial carcinoma is defined as a variant of urothelial carcinoma with cells with glycogen-rich cytoplasm. The clarity of the cells may simulate clear cell renal cell carcinoma or clear cell carcinomas for other organs (Lopez-Beltran et al. 2019).
Foci of clear cells are present in about 30% of high-grade urothelial carcinoma. The pure glycogen-rich urothelial carcinoma represents an unusual variant with few cases reported so far (Kramer et al. 2012; Knez et al. 2014; Zhang et al. 2014; Moradi et al. 2017).
It occurs in adult age.
It presents a male predominance.
It occurs mainly in the bladder, and it however may involve the urinary tract organs in pure form or more common with urothelial carcinoma conventional type (Perez-Montiel et al. 2006).
References and Further Reading
- Oliva, E., Amin, M. B., Jimenez, R., et al. (2002). Clear cell carcinoma of the urinary bladder: A report and comparison of four tumors of Müllerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. The American Journal of Surgical Pathology, 26, 190–197.CrossRefPubMedGoogle Scholar