Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Urothelial Carcinoma, Clear Cell (Glycogen-Rich) Type

  • Rita Canas-Marques
  • Maria Rosaria Raspollini
  • Alessia Cimadamore
  • Rodolfo Montironi
  • Antonio Lopez-BeltranEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4982-1



Clear cell glycogen-rich urothelial carcinoma is defined as a variant of urothelial carcinoma with cells with glycogen-rich cytoplasm. The clarity of the cells may simulate clear cell renal cell carcinoma or clear cell carcinomas for other organs (Lopez-Beltran et al. 2019).

Clinical Features

  • Incidence

    Foci of clear cells are present in about 30% of high-grade urothelial carcinoma. The pure glycogen-rich urothelial carcinoma represents an unusual variant with few cases reported so far (Kramer et al. 2012; Knez et al. 2014; Zhang et al. 2014; Moradi et al. 2017).

  • Age

    It occurs in adult age.

  • Sex

    It presents a male predominance.

  • Site

    It occurs mainly in the bladder, and it however may involve the urinary tract organs in pure form or more common with urothelial carcinoma conventional type (Perez-Montiel et al. 2006).

  • Treatment


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References and Further Reading

  1. Knez, V. M., Barrow, W., Lucia, M. S., et al. (2014). Clear cell urothelial carcinoma of the urinary bladder: A case report and review of the literature. Journal of Medical Case Reports, 8, 275.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Kramer, M. W., Abbas, M., Pertschy, S., et al. (2012). Clear-cell variant urothelial carcinoma of the bladder: A case report and review of the literature. Rare Tumors, 4, 153–155.CrossRefGoogle Scholar
  3. Lopez-Beltran, A., Henriques, V., Montironi, R., et al. (2019). Variants and new entities of bladder cancer. Histopathology, 74, 77–96.CrossRefPubMedGoogle Scholar
  4. Moradi, M., Shojaei, S., Kaseb, K., & Rezaee, H. (2017). Primary clear cell carcinoma of urinary bladder: A case report. Urology Case Reports, 16, 41–43.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Oliva, E., Amin, M. B., Jimenez, R., et al. (2002). Clear cell carcinoma of the urinary bladder: A report and comparison of four tumors of Müllerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. The American Journal of Surgical Pathology, 26, 190–197.CrossRefPubMedGoogle Scholar
  6. Paner, G. P., Annaiah, C., Gulmann, C., et al. (2014). Immunohistochemical evaluation of novel and traditional markers associated with urothelial differentiation in a spectrum of variants of urothelial carcinoma of the urinary bladder. Human Pathology, 45, 1473–1482.CrossRefPubMedGoogle Scholar
  7. Perez-Montiel, D., Wakely, P. E., Hes, O., et al. (2006). High-grade urothelial carcinoma of the renal pelvis: Clinicopathologic study of 108 cases with emphasis on unusual morphologic variants. Modern Pathology, 19, 494–503.CrossRefPubMedGoogle Scholar
  8. Zhang, Y., Huang, J., Feng, H., & Tang, Y. (2014). Primary multiple clear cell variant urothelial carcinomas of urinary bladder: A rare case report. International Journal of Clinical and Experimental Pathology, 7, 3385–3388.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Rita Canas-Marques
    • 1
  • Maria Rosaria Raspollini
    • 2
  • Alessia Cimadamore
    • 3
  • Rodolfo Montironi
    • 3
  • Antonio Lopez-Beltran
    • 1
    • 4
    Email author
  1. 1.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  2. 2.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  3. 3.Institute of Pathological Anatomy and HistopathologyPolytechnic University of the Marche Region AnconaAnconaItaly
  4. 4.Department of Surgery and PathologyUniversity of Cordoba Medical SchoolCordobaSpain