Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Urinary Tract Villous Adenoma

  • Maria Rosaria RaspolliniEmail author
  • Antonio Lopez-Beltran
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4977-1



Benign exophytic glandular tumor.

Clinical Features

  • Incidence

    It is a rare tumor which arises from a metaplastic process of the urothelium.

  • Age

    It occurs mainly in elderly patients: mean age 65 years, range 23–94.

  • Sex

    There is reported a male predominance.

  • Site

    The urachus and the bladder dome and the trigone are the most common site.

  • Treatment

    The treatment is surgical excision of the tumor.

  • Outcome

    Prognosis is excellent; however the progression to adenocarcinoma has been reported in 20% of the cases when the lesion has not been completely resected.


Grossly, it appears as an exophytic lesion.


Histological findings of villous adenoma in the urinary tract, which are the same of villous adenoma in the intestinal tract, include a delicate fibrovascular stalk lined with columnar cells (Fig. 1). The cells may present crowding, hyperchromasia, and prominent nucleoli with pseudostratified nuclei and uncommon non-atypical mitoses. The...
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References and Further Reading

  1. Channer, J. L., Williams, J. L., & Henry, L. (1993). Villous adenoma of the bladder. Journal of Clinical Pathology, 46, 450–452.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Cheng, L., Montironi, R., & Bostwick, D. G. (1999). Villous adenoma of the urinary bladder: A report of 23 cases, including 8 with coexistent adenocarcinoma. The American Journal of Surgical Pathology, 23, 764–771.CrossRefPubMedGoogle Scholar
  3. Seibel, J. L., Prasad, S., Weisse, R. E., et al. (2002). Villous adenoma of the urinary bladder: A lesion frequently associated with malignancy. Human Pathology, 33, 236–241.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Maria Rosaria Raspollini
    • 1
    Email author
  • Antonio Lopez-Beltran
    • 2
    • 3
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain